Results 31 to 40 of about 261 (136)

Cancer treatment monitoring using cell-free DNA fragmentomes. [PDF]

Nat Commun
AbstractCirculating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction, DELFI-TF) using low-coverage whole genome sequencing to determine the cfDNA tumor fraction and validate ...
van 't Erve I, Alipanahi B, Lumbard K, Skidmore ZL, Rinaldi L, Millberg LK, Carey J, Chesnick B, Cristiano S, Portwood C, Wu T, Peters E, Bolhuis K, Punt CJA, Tom J, Bach PB, Dracopoli NC, Meijer GA, Scharpf RB, Velculescu VE, Fijneman RJA, Leal A.   +21 more
europepmc   +6 more sources

Cell-free DNA fragmentomics: a universal framework for early cancer detection and monitoring. [PDF]

Am J Clin Exp Immunol
Cell-free DNA (cfDNA) fragmentomics has emerged as a powerful and noninvasive approach for cancer detection, characterization, and monitoring. By analyzing genome-wide fragmentation patterns - including fragment length distributions, end motifs, nucleosome footprints, and copy number variations - cfDNA fragmentomics provides high-resolution insights ...
Dong W, Hu W, Lu Y, Zheng Q.
europepmc   +3 more sources

The Peptide MS/MS-Fragmentome: A Set of Predictable Fragment Ions with Highly Redundant Sequence Information [PDF]

, 2006
Upon low energy collision induced dissociation (CID), multiply protonated peptides generate a set of interdependent fragment ions detectable by MS/MS, the '[peptide]n+-fragmentome'.
Lehmann, Wolf D., Rappsilber, Juri, Wei, Junhua, Salek, Mojiborahman   +3 more
core   +1 more source

S225: CIRCULATING TUMOR DNA IS A PROGNOSTIC BIOMARKER AT BASELINE AND IMPROVES THE ACCURACY OF INTERIM PET IN CLASSIC HODGKIN LYMPHOMA

, 2022
HemaSphere, Volume 6, Issue S3, Page 126-127, June 2022.
M. C. Pirosa, A. Bruscaggin, L. Terzi di Bergamo, M. Salehi, K. Pini, V. Spina, S. Bocchetta, A. Condoluci, G. Forestieri, D. Piffaretti, J. Marques De Almeida, S. Annunziata, F. Bergesio, E. Borsatti, P. Bulian, S. Chauvie, C. Marco, D. T. Martina, G. Bernhard, M. Kurlapski, A. Moccia, R. Moia, A. Rinaldi, M. Rodari, G. Romanowicz, G. M. Sacchetti, A. Stasia, A. Stathis, G. Stüssi, I. Zangrilli, L. M. Larocca, A. Pinto, A. Santoro, F. Cavalli, E. Zucca, V. Gattei, J. M. Zaucha, C. Carlo‐Stella, S. Hohaus, G. Gaidano, L. Ceriani, D. Rossi   +41 more
wiley   +1 more source

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models

PLOS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood. We explored the roles of deoxyribonuclease 1 (DNASE1) and deoxyribonuclease 1-like 3 (DNASE1L3) in the fragmentation of ucfDNA using mouse models.
Meihui Chen, Rebecca W. Y. Chan, Peter P. H. Cheung, Meng Ni, Danny K. L. Wong, Ze Zhou, Mary-Jane L. Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O. Lui, W. K. Jacky Lam, Jeremy Y. C. Teoh, Chi-Fai Ng, Peiyong Jiang, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo   +18 more
openaire   +3 more sources

Bioactive conformational ensemble server and database. A public framework to speed up in silico drug discovery. [PDF]

, 2021
Modern high-throughput structure-based drug discovery algorithms consider ligand flexibility, but typically with low accuracy, which results in a loss of performance in the derived models.
Bayarri, Genís, Soliva, Robert, Orozco López, Modesto, Colizzi, Francesco, Zivanovic, Sanja, Moreno Fajardo, David Fernando, Gelpí Buchaca, Josep Lluís, Hospital Gasch, Adam   +7 more
core   +1 more source

Fragmentomics of natural peptide structures

Biochemistry (Moscow), 2009
Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire   +4 more sources

AGE-ASSOCIATED VARIABILITY OF CIRCULATING FREE DNA CHARACTERISTICS: GENOME-WIDE ANALYSIS

Journal of Bioinformatics and Genomics
The fragments of circulating free DNA (cfDNA) found in plasma are formed due to the genomic DNA degradation during cellular death. The present study is the first research of age-associated variability of cfDNA characteristics performed on the group of ...
Meshkov I.O., Remizova J.A., Makarova A.S., Primova A.A., Petrova V.A., Bukhanova A.A., Kumar N.A., Ivashechkin A.A., Makhotenko A.V., Snigir E.A., Makarov V.V., Yudin V.S., Keskinov A.A., Yudin S.M.   +13 more
doaj   +1 more source

Innovations in Early Lung Cancer Detection: Tracing the Evolution and Advancements in Screening. [PDF]

J Clin Med
Lung cancer mortality rates, particularly non-small cell lung cancer (NSCLC), continue to present a significant global health challenge, and the adoption of lung cancer screening remains limited, often influenced by inequities in access to healthcare ...
Cotton LB, Bach PB, Cisar C, Schonewolf CA, Tennefoss D, Vachani A, Carter-Bawa L, Zaidi AH.   +7 more
europepmc   +2 more sources

Fragmentomics features of ovarian cancer

International Journal of Cancer
AbstractOvarian cancer (OC) is a major cause of cancer mortality in women worldwide. Due to the occult onset of OC, its nonspecific clinical symptoms in the early phase, and a lack of effective early diagnostic tools, most OC patients are diagnosed at an advanced stage.
Xiaopei Chao, Zhentian Kai, Huanwen Wu, Jing Wang, Xiaojing Chen, Haiqi Su, Xiao Shang, Ruijue Lin, Lisha Huang, Hongsheng He, Jinghe Lang, Lei Li   +11 more
openaire   +2 more sources