Results 41 to 50 of about 1,521,389 (308)

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

Frontiers in Immunology
COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the ...
Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova   +20 more
doaj   +1 more source

Current Trends in Diagnostics of Viral Infections of Unknown Etiology

Viruses, 2020
Viruses are evolving at an alarming rate, spreading and inconspicuously adapting to cutting-edge therapies. Therefore, the search for rapid, informative and reliable diagnostic methods is becoming urgent as ever.
Daniel Kiselev, Alina Matsvay, Ivan Abramov, Vladimir Dedkov, German Shipulin, Kamil Khafizov   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods

Frontiers in Medicine
IntroductionMinimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). The blood plasma circulating cell-free DNA (cfDNA) fragments reflect the genome and chromatin status and are considered as integral ...
Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova   +17 more
doaj   +1 more source

Determination of defence capability requirements [PDF]

Војно дело, 2016
A capability-based planning approach provides defence system with adequate response in facing uncertainty, economic constraints and risks. Determination of required defence capabilities is the most important and complex phase in capability-based planning
Stojković Dejan S., Kankaraš Milan S., Mitić Vlada M.   +2 more
doaj   +1 more source

Climate Change Adaption between Governance and Government—Collaborative Arrangements in the City of Munich

Land, 2022
Growing cities face severe land use conflicts. Urban expansion and the densification of existing built areas are increasing the pressure on green spaces, which are key for climate change adaptation.
Simone Linke, Sabrina Erlwein, Martina van Lierop, Elizaveta Fakirova, Stephan Pauleit, Werner Lang   +5 more
doaj   +1 more source

Educational Development and Strategic Planning [PDF]

, 2007
Teaching is an intervention which allows someone to learn as fully as they are able. Universities and colleges should provide students with the structures and support they need to learn, and recognise and minimise the barriers to learning which do not ...
Wareing, Shan
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development and validation of a PCR test for rapid molecular diagnosis of macrolide-resistant Mycoplasma pneumoniae [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To develop and conduct the first stage of validation for a PCR test that identifies key mutations in the V domain of the 23S rRNA gene of M. pneumoniae (A2058G, A2059G, and A2062C).
Danilov D.I., Savochkina Yu.A., Edelstein I.A., Adeshkina N.I., Oleynik O.N., Gordukova M.A., Shipulin G.A.   +6 more
doaj   +1 more source

Maximizing Foundation Effectiveness: Aligning Program Strategy, Organizational Capacity, Strategic Planning, and Performance Assessment to Achieve Success [PDF]

, 2008
This paper outlines a framework for increasing the philanthropic performance of an organization by focusing on strategic planning and development of tight logic models for the organization's programs.
Paul Connolly
core