Results 51 to 60 of about 135,944 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Determination of defence capability requirements [PDF]
Војно дело, 2016 A capability-based planning approach provides defence system with adequate response in facing uncertainty, economic constraints and risks. Determination of required defence capabilities is the most important and complex phase in capability-based planning
Stojković Dejan S. +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation
Computational and Structural Biotechnology JournalAssessing the selectivity of binding a small molecule with proteins remains a fundamental yet unresolved challenge in computational drug discovery. Conventional strategies for estimating ligand selectivity depend on exhaustive cross-prediction of binding
Anna Tashchilova +9 more
doaj +1 more source
Development and validation of a PCR test for rapid molecular diagnosis of macrolide-resistant Mycoplasma pneumoniae [PDF]
Клиническая микробиология и антимикробная химиотерапияObjective. To develop and conduct the first stage of validation for a PCR test that identifies key mutations in the V domain of the 23S rRNA gene of M. pneumoniae (A2058G, A2059G, and A2062C).
Danilov D.I. +6 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Nursing Management (Springhouse), 1993 Strategic planning identifies a department's environmental factors while establishing its purpose, mission, philosophy and goals and developing a long-range plan and objectives. This hospital's practical approach mirrors the nursing process related to assessment, diagnosis and planning, implementation and evaluation.
openaire +5 more sources
Associations between the level of IGF-1 and geriatric syndromes in nonagenarians
Российский журнал гериатрической медициныBACKGROUND. The role of insulin-like growth factor-1 (IGF-1) and its levels in aging have been established in clinical and experimental studies. Aging-associated geriatric syndromes underlie functional and adaptive decline in older patients.
A. K. Ilyushchenko +14 more
doaj +1 more source
Requisites to Strategic Planning
Archives of Pathology & Laboratory Medicine, 2015 Until a few years ago, the business environment for the practice of pathology was robust: stable third-party reimbursement, high revenues, content customers, and negligible competition. However, that environment is changing and the future does not look so favorable. Reduced federal and third-party reimbursements will diminish practice revenues. Fee-for-
David A, Novis +2 more
openaire +2 more sources