Results 51 to 60 of about 1,521,389 (308)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Developing and feasibility testing of Hamdard Force: an intervention to build the capacity of a community mental health workforce in Pakistan

BMC Public Health
Background As part of a Mental Health and Psychosocial Support (MHPSS) initiative, this study presents the process of developing an intervention to build the capacity of a community mental health workforce in Pakistan - Hamdard Force (HF).
Asma Humayun, Arooj Najmussaqib, Noor ul Ain Muneeb   +2 more
doaj   +1 more source

Hormonal and metabolic status of centenarians diagnosed with sarcopenia: Prospective, Observational Study

Российский журнал гериатрической медицины
RELEVANCE: Sarcopenia is one of the leading geriatric syndromes that increases the risk of disability, falls and injuries. This syndrome is of particular importance for centenarians aged 90 years and older, for whom a detailed analysis of the course of ...
L. V. Matchekhina, O. N. Tkacheva, E. M. Shelley, A. A. Mamchur, V. V. Erema, M. V. Bruttan, M. V. Ivanov, D. A. Kashtanova, A. M. Rumyantseva, V. S. Yudin, V. V. Makarov, A. A. Keskinov, S. A. Kraevoy, S. M. Yudin, I. D. Strazhesko   +14 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Associations between the level of IGF-1 and geriatric syndromes in nonagenarians

Российский журнал гериатрической медицины
BACKGROUND. The role of insulin-like growth factor-1 (IGF-1) and its levels in aging have been established in clinical and experimental studies. Aging-associated geriatric syndromes underlie functional and adaptive decline in older patients.
A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, E. M. Shelley, A. A. Mamchur, V. V. Erema, M. V. Ivanov, D. A. Kashtanova, A. M. Rumyantseva, V. S. Yudin, V. V. Makarov, A. A. Keskinov, S. A. Kraevoy, S. M. Yudin, I. D. Strazhesko   +14 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A study of subsidiaries views of information systems strategic planning in multinational organisations [PDF]

, 2007
This research examines information systems strategic planning (ISSP) in multinationals from the perspective of the subsidiaries. The research was carried out through interviews with the IT and business managers in subsidiaries of nine large American ...
Mohdzaher, Mohdzain, Ward, John
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Search for signals of positive selection of circadian rhythm genes PER1, PER2, PER3 in different human populations

Вавиловский журнал генетики и селекции
The diversity of geographically distributed human populations shows considerable variation in external and internal traits of individuals. Such differences are largely attributed to genetic adaptation to various environmental influences, which include ...
A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva   +10 more
doaj   +1 more source

FY13 Planning Task Force Documents: University Library System, University of Pittsburgh, August 2011-June 2012 [PDF]

, 2012
These documents provide a record of the work of the ULS FY13 Planning Task Force, which initiated and deployed a highly inclusive strategic planning process to analyze the library's strategic options, prioritize them, and identify key actions for ...
Arroyo-Ramirez, Elvia M, Calhoun, Karen, Card, Heidi, Ferdinand, Luke   +3 more
core   +1 more source