Results 51 to 60 of about 249,873 (317)

Search for signals of positive selection of circadian rhythm genes PER1, PER2, PER3 in different human populations

Вавиловский журнал генетики и селекции
The diversity of geographically distributed human populations shows considerable variation in external and internal traits of individuals. Such differences are largely attributed to genetic adaptation to various environmental influences, which include ...
A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva   +10 more
doaj   +1 more source

Requisites to Strategic Planning

Archives of Pathology & Laboratory Medicine, 2015
Until a few years ago, the business environment for the practice of pathology was robust: stable third-party reimbursement, high revenues, content customers, and negligible competition. However, that environment is changing and the future does not look so favorable. Reduced federal and third-party reimbursements will diminish practice revenues. Fee-for-
David A, Novis, Michelle, Mudge-Riley, Marko, Raich   +2 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Strategic Takt Planning [PDF]

Annual Conference of the International Group for Lean Construction
Reports on the use of takt tend to focus on applications aimed at so-called operational takt planning. Instead, this paper focuses on strategic takt planning. Strategic- and operational takt planning must go hand in hand. Specifically, strategic takt planning is required upfront in project delivery as it informs prospective contractors what is expected
Tommelein, ID, Emdanat, S
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Key Strategic Planning Questions

, 2015
A compilation of key strategic planning questions gathered from the Board of Trustees, the Strategic Planning website, interviews with key stakeholders, and the PSU Foundation ...
Strategic Planning Development Team
core  

Strategic Planning: Processes, Tools and Outcomes

, 1999
First published in 1999, this book examines the 'how' and 'why' of strategic planning, illustrates the vital role it plays in our day-to-day lives and explores its potential for helping to ensure the future viability of humanity and of the cultures and ...
Chambers, L., Taylor, M.A.P.
core   +1 more source

Supervision-based evaluation of primary healthcare workers’ performance after mhGAP-HIG training in Pakistan

SSM - Mental Health
Background: The province of Khyber Pakhtunkhwa (KP) in Pakistan faces significant gaps in mental health services, marked by limited resources and inequitable distribution of services. To strengthen the existing services in nine districts of the province,
Asma Humayun, Arooj Najmussaqib, Noor ul Ain Muneeb   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source