Results 101 to 110 of about 6,830,368 (376)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Modernization of the Mechanism of State Regulation of Regional Russian Agro-Industrial Complex Under New Social and Economic Constructs

Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 3, Èkonomika,Èkologiâ, 2014
The article highlights the obstacles in building the necessary amount of food and in ensuring the full import substitution based on the efficient use of the available resources: Russia’s lagging behind economically developed countries in the technical ...
Babich Tatyana Vladimirovna, Mikhaylova Nataliya Aleksandrovna, Smirnova Olga Sergeevna   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimal eco-label choice strategy for environmentally responsible corporations considering government regulations

, 2023
Yingjie Hou, Peng Guo, Devika Kannan, Kannan Govindan   +3 more
openalex   +1 more source

Privatization Incentives – A Wage Bargaining Approach [PDF]

We analyze the incentives of a government to privatize a state owned firm. Assumingprice cap regulation, a unionized labor market and wage bargaining the government’sgains from privatization depend on two effects.
Andreas Kuhlmann
core  

Government Regulation [PDF]

, 2005
. Interest in the use of so-called voluntary approaches to supplement or replace formal environmental regulation is on the rise, both in Europe and in the United States.
Ashford, Nicholas A., Caldart, Charles
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Tidal Exclusion Barriers Fragment an Invertebrate Community into Taxonomically and Functionally Distinct Estuarine and Wetland Assemblages

Journal of Marine Science and Engineering
Various types of tidal barriers are used in estuaries to reduce saltwater intrusion and regulate freshwater discharge, but they often alter the physicochemical environment and faunal composition.
Sorcha Cronin-O’Reilly, Alan Cottingham, Linda H. Kalnejais, Kath Lynch, James R. Tweedley   +4 more
doaj   +1 more source

The World Experience and a Unified Model for Government Regulation of Development of the Automotive Industry

, 2019
The article summarises the advanced world experience in government regulation of the automotive industry using the example of the leading automotive manufacturing countries – China, Japan, India, South Korea, the USA, and the European Union.
I. Dmytriiev, I. Shevchenko, V. Kudryavtsev, Olena M. Lushnikova, Tetiana S. Zhytnik   +4 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source