Results 181 to 190 of about 6,830,368 (376)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Governance Reform of German food safety regulation: Cosmetic or real? [PDF]

open access: yes
Discussion of institutional changes made by the German government in response to the emergence of the first cases of BSE in Germany in 2000. Due to the establishment of a large-scale private sector quality assurance scheme, regulation moved away from ...
Steiner, Bodo
core   +1 more source

Institutional Policies on Artificial Intelligence in Higher Education: Frameworks and Best Practices for Faculty

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article explores institutional policies on artificial intelligence (AI) in higher education. As AI tools become increasingly utilized in academia—from research and teaching to assessment and student support—institutions face growing pressure to establish clear, ethical, and practical guidelines to help guide faculty.
Lauren Azevedo   +3 more
wiley   +1 more source

Patterns in Transvaginal Mesh Surgery After Government Regulation in the United States.

open access: yesJAMA Surg, 2022
Lewicki P   +5 more
europepmc   +1 more source

Essays on government regulation and government governance structure

open access: yes, 2017
This thesis consists of two independent studies. The first study works on the effect of government regulation on financial markets. The second study analyses the multitask nature of government regulation in a regionally decentralized authoritarian regime.
openaire   +1 more source

The Grand Experiment in Regulatory Reporting [PDF]

open access: yes
This paper evaluates a grand regulatory experiment, the first of its kind in the world, aimed at providing an objective and comprehensive characterization of the costs and benefits of U.S.
Hahn, Robert W., Muething, Mary Beth
core   +1 more source

Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank   +3 more
wiley   +1 more source

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