Results 91 to 100 of about 1,108,976 (316)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Federal Home Loan Bank System: An Overview of Changes and Current Issues Affecting the System [PDF]
, 2005 Testimony issued by the Government Accountability Office with an abstract that begins "The FHLBank System (FHLBank System or System) is a government-sponsored enterprise (GSE) that consists of 12 Federal Home Loan Banks (FHLBanks) and is cooperatively ...
United States. Government Accountability Office.
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Decentralisation: does the New Zealand local government system measure up? [PDF]
, 2015 Decentralisation continues to be well received as a strategy for improving the governance of countries and delivering more responsive and efficient services.
Reid, Mike, Mike Reid
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Methodology of the study of institutional design: Philosophical and critical analysis [PDF]
Известия Саратовского университета. Новая серия: Серия Философия. Психология. ПедагогикаIntroduction. In one of its roles political philosophy can act as a theoretical and methodological level of political science, and in this sense is necessary for the full development of the latter.
Kornievsky, Alexey A.
doaj +1 more source
Governance Systems Analysis (GSA): A Framework for Reforming Governance Systems
Journal of Public Administration and Governance, 2013 Most commentators understand that contemporary social, economic and environmental challenges require quality governance from global to local scales. While public scrutiny of governance has increased in recent years, the literature on frameworks and methods for analysis in complex, poly-centric and multi-thematic governance systems remains fragmented ...
Dale, Allan, Vella, Karen, Potts, Ruth
openaire +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Policy Analysis of the Regional Government System : Focusing on the State Government System
, 1989 The prefectural system in Japan, unchanged for three hundred years, has been unable to adapt to meet the increasing public needs of a highly urbanized society.
3807 +2 more
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, 2023 As required by Parliament, the Government report on the Senate Group and the management of central government premises is intended to provide a comprehensive review of the management of the central government's real estate and premises and of the ...
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source