Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Linked Data is an innovative approach for publishing heterogeneous data sources on the web. As such, it can transcend the traditional confines of separate databases, as well as the confines of separate institutions.
Erwin Folmer +4 more
doaj +1 more source
THE ELEMENTS OF THE APPLICATION OF THE EXPANDED RULE AS AN INPUT TO IMPROVE THE ENVIRONMENTAL SITUATION IN EGYPT - AN EMPIRICAL STUDY [PDF]
The research aims to study the concept of Environmental Governance and dimensions and effervescence and analysis of environmental government policies toward activating the participation of non-governmental organizations in carrying out environmental ...
Noman A. M. +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Comparison of the Safety Levels of Governmental and Non-Governmental Schools: Study in Yazd City, Iran, 2009 [PDF]
The school environment is an environment wherein a student spends one third of his life with teachers and other students. In the present study, the safety levels of governmental and non-governmental schools were studied and compared.
Gholam Hossein Halvani, Damon Ketabi
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Kadaster Knowledge Graph: Beyond the Fifth Star of Open Data
After more than a decade, the supply-driven approach to publishing public (open) data has resulted in an ever-growing number of data silos. Hundreds of thousands of datasets have been catalogued and can be accessed at data portals at different ...
Stanislav Ronzhin +6 more
doaj +1 more source
From governing through data to governmentality through data: Artefacts, strategies and the digital turn [PDF]
The article argues that current discussions about governance through data in education can be fruitfully extended through: (1) the establishment of connections with wider debates about the role of commensuration processes and governmentality in the recreation of education systems; (2) greater emphasis on the ‘artefacts’ through which data ...
Souto-Otero, M., Beneito-Montagut, R.
openaire +2 more sources

