Results 61 to 70 of about 161,363 (262)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Multi-Agent Deep Reinforcement Learning System for Governmental Interoperability

Applied Sciences
This study explores the integration of the JADE (Java Agent Development Framework) platform with deep reinforcement learning (DRL) to enhance governmental interoperability and optimize administrative workflows in municipal settings. The proposed approach
Azanu Mirolgn Mequanenit, Eyerusalem Alebachew Nibret, Pilar Herrero-Martín, María S. García-González, Rodrigo Martínez-Béjar   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Oral PrEP use and intention to use long-acting PrEP regimens among MSM accessing PrEP via governmental and non-governmental provision pathways, 20 European countries, October 2023 to April 2024

Eurosurveillance
BACKGROUND Pre-exposure prophylaxis (PrEP) provision routes across Europe differ notably between governmental and non-governmental pathways. The introduction of long-acting (LA)-PrEP may further diversify provision dynamics.
Kai J Jonas
doaj   +1 more source

Validation of the Structural Model of Open Data Governance in Line with the Health of the Administrative System in E-government [PDF]

International Journal of Digital Content Management
Purpose: The current research was conducted with the aim of validating the structural model of open data governance in line with the health of the administrative system in e-government in government organizations.
Ahmad Sami, Masoud Ahmadi, Changiz Mohammadizadeh   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Big Data in Governmental Transparency and Accountability

American Journal of Data Science and Analysis
Big data analytics is transforming governmental operations by enhancing transparency, accountability, and public trust. Through the use of open data initiatives, artificial intelligence (AI), and machine learning (ML), governments can analyze vast amounts of data to detect corruption, improve decision-making, and ensure policy compliance.
openaire   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Novel integration of governmental data sources using machine learning to identify super-utilization among U.S. counties. [PDF]

Intell Based Med, 2023
Ricket IM, Matheny ME, MacKenzie TA, Emond JA, Ailawadi KL, Brown JR.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source