Results 41 to 50 of about 71,655 (295)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An Intoroductory Study of Regional Governmental Structure in Palhae 渤海 [PDF]
, 1983 Fu 府 and zhou 州, governmental units modeled upon governmental systems of Koguryo 高句麗, were established in Palhae to rule the area. They functioned both as administrative organizations and as military organizations.
河上, 洋
core +1 more source
Frontiers in Environmental ScienceMethodsThis study constructs a quasi-natural experiment leveraging the pilot policy for climate resilient cities construction (CRCC), utilizing panel data from 296 prefecture-level cities in China spanning from 2006 to 2022. The Difference-in-Differences
Chen Gao +3 more
doaj +1 more source
A comparative study of voluntary disclosure under Article 44 of the companies listed on Tehran Stock Exchange: before and after transfer [PDF]
بررسیهای حسابداری و حسابرسی, 2016 This study examines the level of voluntary disclosure in Iranian companies. It is examined if the volume of voluntary disclosure is influenced by transferring a governmental company to private sector.
Ahmad Nasseri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2015 The purpose of research refers to comparison of Ukrainian and the USA standards of preparation and presentation of governmental entities financial reports with the aim of implementation of foreign experience regarding financial data disclosure of a ...
Ambarchian V.S.
doaj
Європейські історичні студії, 2018 The article analyzes one of the areas of the operational work of the War Refugee Board, an American governmental agency that emerged at the end of the World War II.
Volodymur Yushkevych
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source