Results 51 to 60 of about 505,257 (335)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Critical discourse analysis, description, explanation, causes: Foucault's inspiration versus Weber's perspiration [PDF]

open access: yes, 2008
The FOUCAULTian governmentality approach, in relying on a teleology - the ultimate purpose of human endeavour is the quest for ever-growing human reason, a reason that is the universal basis of moral judgements, especially moral judgements about ...
Kendall, G., Wickham, G.
core   +1 more source

‘Just be confident girls!’: Confidence Chic as Neoliberal Governmentality [PDF]

open access: yes, 2017
In our injurious patriarchal cultures, unconfidence is almost inescapable when inhabiting womanhood. However, recently the promotion of self-confidence has surfaced as the site for expanded, heightened and more insidious modes of regulation, often ...
Favaro, L.
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

THE LIMITS OF GLOBAL GOVERNANCE: GOVERNMENTALITY AS AN ANALYTICAL ALTERNATIVE

open access: yesMonções, 2019
In this present article, I seek to demonstrate the possible contributions that the concept of “governmentality” can bring to the International Relations area, specifically, in the discussion about governance.
Vitor Furtado Jerônimo Veloso
doaj   +1 more source

Risky Choices

open access: yesNew Zealand Journal of Teachers' Work, 2021
Achievement data from New Zealand secondary schools suggest that students from lower socio-economic communities have fewer opportunities to engage with complex content in subject English.
Claudia Rozas Gómez
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Are retrofitted social houses sufficiently reflecting the holistic health and wellbeing requirements of older people? [PDF]

open access: yes, 2018
There is a requirement to address the needs of the most at risk individuals in society through robust policies designed to improve the energy performance of buildings and safeguard the wellbeing of the elderly from the known vulnerabilities of their ...
Callaghan, Nicola   +2 more
core   +3 more sources

Foucault and the Invisible Economy

open access: yesFoucault Studies, 2009
This paper discusses the extent to which governmentality provides a critical visibility of the economy beyond its liberal imaginary. It argues that Foucault’s conceptual and historical understanding of liberal governmentality has two traits that ...
Ute Tellmann
doaj   +1 more source

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