Results 151 to 160 of about 34,464 (236)

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

open access: yesMacromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger   +8 more
wiley   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

open access: yesMacromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh   +8 more
wiley   +1 more source

Antimicrobial Cyclic Peptidomimetics

open access: yesMacromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Arsonic Acid Functional Polymers Enable Stabilization of Iron Oxide Nanoparticles in Aqueous Solution

open access: yesMacromolecular Rapid Communications, EarlyView.
Arsonic acid containing diblock copolymers are developed to incorporate arsonic acid moieties for surface anchoring to IONPs, along with water soluble PEG blocks to impart colloidal stability in aqueous environments. The resulting polymer‐coated IONPs are evaluated for stability in physiological media and cytocompatibility.
Nhu Thao Huynh   +10 more
wiley   +1 more source

Identification and characterization of QTL for grain protein content derived from the D genome of allohexaploid wheat. [PDF]

open access: yesFront Plant Sci
Luo X   +11 more
europepmc   +1 more source

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