Disruption of the l ‐ DOPA Receptor Gpr143/OA1 ‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype [PDF]
Neuropsychopharmacology ReportsGPR143, originally identified as the gene product of ocular albinism 1 (OA1), a G protein‐coupled receptor (GPCR), can function as a receptor for l‐3,4‐dihydroxyphenylalanine (DOPA), a precursor of dopamine (DA).
Masashi Asai, Yayoi Kimura
exaly +4 more sources
A Mitoxyperilysis-Related Single-Cell and Machine-Learning Framework Defines an Immune-Cold Melanoma Phenotype and a Robust Prognostic Signature. [PDF]
Hum MutatMitoxyperilysis is a mitochondria‐dependent membrane lysis process driven by innate immune and metabolic cues, yet its clinical relevance in melanoma remains unclear. We analyzed single‐cell RNA‐seq data (GSE215120) to quantify a mitoxyperilysis‐related score (MRS), resolve cell‐type heterogeneity, and compare predicted cell–cell communication between ...
Zhou Y +6 more
europepmc +2 more sources
Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate
Journal of Pharmacological Sciences, 2023 Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4 ...
Akitoyo Hishimoto +2 more
exaly +3 more sources
Differences of ocular oscillations and neuro-retinal structures in patients with nystagmus caused by GPR143 and FRMD7 gene variants [PDF]
Indian Journal of OphthalmologyPurpose: Mutations of G protein-coupled receptor 143 (GPR143) and FERM domain containing 7 (FRMD7) may result in congenital nystagmus (CN) in the first 6 months of life.
Lijuan Huang, Biru Xu, Ningdong Li
doaj +2 more sources
l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice
Journal of Pharmacological Sciences, 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson's disease patients. We recently identified GPR143 as a candidate receptor for l-DOPA.
Yoshio Goshima +2 more
exaly +3 more sources
Journal of Pharmacological Sciences, 2019 Neurite outgrowth is a complex differentiation process regulated by external and/or internal mechanisms. Among external mechanisms, G-protein coupled receptors (GPCRs) have been implicated in this process, but the pathways involved are not fully ...
Yoshio Goshima, Daiki Masukawa
exaly +3 more sources
Novel mutations of the X-linked genes associated with early-onset high myopia in five Chinese families [PDF]
BMC Medical Genomics, 2023 Purpose To report novel pathogenic variants of X-linked genes in five Chinese families with early-onset high myopia (eoHM) by using whole-exome sequencing and analyzing the phenotypic features. Methods 5 probands with X-linked recessive related eoHM were
Feiyin Zi +5 more
doaj +2 more sources
Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls. [PDF]
Pigment Cell Melanoma ResThe colouration of the ventral face of barn owls varies from white to rufous, depending on the MC1R (V126I) genotype. This colouration is linked to multiple fitness and behavioural traits. Genes linked to neurotransmitters and synapses are upregulated with melanin genes in a transcriptome of growing feathers from the ventral part of chicks of the ...
Ducrest AL +16 more
europepmc +2 more sources
Multilevel Genetic and Functional Assessment of an ARR3 Frameshift Variant in Early-Onset High Myopia. [PDF]
Int J GenomicsBackground Early‐onset high myopia (eoHM) is a highly heritable ocular disorder, with pathogenic variants in the X‐linked ARR3 gene (which encodes cone arrestin) being associated with a female‐limited form of eoHM. However, the clinical manifestations of early truncating variants in ARR3 and their potential impact on the classic sex‐limited pattern ...
Li Y +5 more
europepmc +2 more sources
Transcriptome Profile Analysis Identifies Candidate Genes for the Melanin Pigmentation of Skin in Tengchong Snow Chickens [PDF]
Veterinary Sciences, 2023 Tengchong Snow chickens are one of the most precious, black-boned chickens in Yunnan province and usually produce black meat. However, we found a small number of white meat traits in the chicken population during feeding.
Xiannian Zi +12 more
doaj +2 more sources