Results 1 to 10 of about 47,936 (214)

Accumulation of l-DOPA in various organs of faba bean and influence of drought, nitrogen stress, and processing methods on l-DOPA yield

Crop Journal, 2018
Faba bean (Vicia faba L.) has been identified as a rich source of l-DOPA, which is used in treating Parkinson's disease. Biosynthesis and accumulation of active substances such as l-DOPA in plant tissues may interact with growing conditions and ...
Fatemeh Etemadi, Masoud Hashemi, Reena Randhir   +2 more
exaly   +3 more sources

L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy [PDF]

npj Parkinson's Disease
L-Dopa, the main Parkinson’s disease treatment, unexpectedly alters the postsynaptic architecture of cultured mouse neurons through its incorporation into α-tubulin via tubulin tyrosine ligase (TTL).
Agustina Zorgniotti, Aditi Sharma, Sacnicte Ramirez-Rios, Chadni Sanyal, Martina Aleman, Yanina Ditamo, Marie-Jo Moutin, C. Gastón Bisig, Leticia Peris   +8 more
doaj   +2 more sources

MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice. [PDF]

Int J Nanomedicine
Onrubia-Márquez M, Garcia MM, Navas F, Martínez-Erro S, Martín A, Morales V, Delaval J, Merchán-Sánchez L, Sánchez-Robles EM, Paniagua NA, Rodríguez-Rivera C, Sanz R, Goicoechea C, García-Muñoz RA.   +13 more
europepmc   +2 more sources

Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA.

PLoS ONE, 2022
Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate.
Shu Taira, Akari Ikeda, Yuki Sugiura, Hitomi Shikano, Shoko Kobayashi, Tsutomu Terauchi, Jun Yokoyama   +6 more
doaj   +1 more source

Effects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cells

Bangladesh Journal of Pharmacology, 2023
This study aimed to investigate the effects of levodopa (L-dopa), p-coumaric acid, and combinations in the neuroblastoma (N1E-115) cell. L-dopa and L-dopa plus p-coumaric acid group caused oxidative stress by increasing 12.5 and 3.7-fold in superoxide ...
Nebiye Pelin Turker, Elvan Bakar
doaj   +1 more source

Irreversible incorporation of L-dopa into the C-terminus of α-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon

Neurobiology of Disease, 2021
L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias.
Agustina Zorgniotti, Yanina Ditamo, Carlos A. Arce, C. Gaston Bisig   +3 more
doaj   +1 more source

L-dopa and arousal [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1974
In 10 patients with Parkinsonism, treatment with L-dopa was associated with a rise in the skin conductance level and its fluctuations, an increased electromyographic activity in the frontalis muscle, and with faster reaction times. The change of skin conductance in response to a loud noise also increased and its habituation to the repetition of the ...
T B, Horvath, R A, Meares
openaire   +2 more sources

L-Dopa and Schizophrenia [PDF]

Canadian Psychiatric Association Journal, 1976
Previous reports have emphasized the deterioration of schizophrenic patients when given L-Dopa. The authors described a patient with long-standing catatonic schizophrenia who was not helped by conventional therapies but initially responded dramatically to L-Dopa.
P E, Garfinkel, H C, Stancer
openaire   +2 more sources

GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming

Neurobiology of Disease, 2020
Levo-dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease; however, most patients develop uncontrollable abnormal involuntary movements known as L-DOPA-induced dyskinesia.
Haruo Nishijima, Fumiaki Mori, Akira Arai, Gang Zhu, Koichi Wakabayashi, Motohiro Okada, Shinya Ueno, Noritaka Ichinohe, Chieko Suzuki, Tomoya Kon, Masahiko Tomiyama   +10 more
doaj   +1 more source

An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices

Separations, 2022
L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family ...
Carmen Tesoro, Filomena Lelario, Rosanna Ciriello, Giuliana Bianco, Angela Di Capua, Maria Assunta Acquavia   +5 more
doaj   +1 more source