Results 101 to 110 of about 98,573 (298)

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Facilitating university admission using a chatbot based on large language models with retrieval-augmented generation

Educational Technology & Society
University admission consultation is a professional service that assists students with the university application process. Typically, accessing this service entails exploring university websites, directly contacting faculty members and officers via phone
Zheng Chen, Di Zou, Haoran Xie, Huajie Lou, Zhiyuan Pang   +4 more
doaj   +1 more source

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source

From Fluoride Removal to Interfacial Reactivity Enhancement: Functionalized La3+‐Crosslinked B/CuO Energetic Microspheres

Advanced Science, EarlyView.
A fluoride adsorption‐functionalization strategy directly couples fluoride wastewater remediation with combustion performance enhancement of B/CuO energetic microspheres. Fluoride captured from wastewater is retained within the microspheres without adsorbent regeneration or disposal, simultaneously achieving pollutant removal and enhanced energetic ...
Hongbiao Huo, Minghao Bao, Zhongbo Han, Wei Shi, Jianyong Xu, Pengfei Cui, Wenchao Zhang   +6 more
wiley   +1 more source

Large Language Models: А Socio-Philosophical Essay

Галактика медиа: журнал медиа исследований
Neural networks have filled the information space. On the one hand, this indicates the scientific and technological movement of contemporary society (perhaps, AGI is already waiting for us outside the door). On the other hand, in everyday discourse there
Regina V. Penner
doaj   +1 more source

An Assessment of GPT-3.5 and GPT-4.0 Responses to Scoliosis FAQs

Journal of Personalized Medicine
Background: ChatGPT is a large language model (LLM) online chatbot developed by OpenAI and launched in November 2022. Early adoption studies have shown high readiness to use this technology for health-related questions and self-diagnosis. However, the quality and clinical adequacy of health-related responses remain incompletely characterized.
Tu-Lan Vu-Han, Enikö Regényi, Vikram Sunkara, Paul Köhli, Friederike Schömig, Alexander P. Hughes, Michael Putzier, Matthias Pumberger, Thilo Khakzad   +8 more
openaire   +2 more sources

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

gpt-oss-120b & gpt-oss-20b Model Card

CoRR
We present gpt-oss-120b and gpt-oss-20b, two open-weight reasoning models that push the frontier of accuracy and inference cost. The models use an efficient mixture-of-expert transformer architecture and are trained using large-scale distillation and reinforcement learning.
OpenAI, Agarwal, Sandhini, Ahmad, Lama, Ai, Jason, Altman, Sam, Applebaum, Andy, Arbus, Edwin, Arora, Rahul K., Bai, Yu, Baker, Bowen, Bao, Haiming, Barak, Boaz, Bennett, Ally, Bertao, Tyler, Brett, Nivedita, Brevdo, Eugene, Brockman, Greg, Bubeck, Sebastien, Chang, Che, Chen, Kai, Chen, Mark, Cheung, Enoch, Clark, Aidan, Cook, Dan, Dukhan, Marat, Dvorak, Casey, Fives, Kevin, Fomenko, Vlad, Garipov, Timur, Georgiev, Kristian, Glaese, Mia, Gogineni, Tarun, Goucher, Adam, Gross, Lukas, Guzman, Katia Gil, Hallman, John, Hehir, Jackie, Heidecke, Johannes, Helyar, Alec, Hu, Haitang, Huet, Romain, Huh, Jacob, Jain, Saachi, Johnson, Zach, Koch, Chris, Kofman, Irina, Kundel, Dominik, Kwon, Jason, Kyrylov, Volodymyr, Le, Elaine Ya, Leclerc, Guillaume, Lennon, James Park, Lessans, Scott, Lezcano-Casado, Mario, Li, Yuanzhi, Li, Zhuohan, Lin, Ji, Liss, Jordan, Lily, Liu, Liu, Jiancheng, Lu, Kevin, Lu, Chris, Martinovic, Zoran, McCallum, Lindsay, McGrath, Josh, McKinney, Scott, McLaughlin, Aidan, Mei, Song, Mostovoy, Steve, Mu, Tong, Myles, Gideon, Neitz, Alexander, Nichol, Alex, Pachocki, Jakub, Paino, Alex, Palmie, Dana, Pantuliano, Ashley, Parascandolo, Giambattista, Park, Jongsoo, Pathak, Leher, Paz, Carolina, Peran, Ludovic, Pimenov, Dmitry, Pokrass, Michelle, Proehl, Elizabeth, Qiu, Huida, Raila, Gaby, Raso, Filippo, Ren, Hongyu, Richardson, Kimmy, Robinson, David, Rotsted, Bob, Salman, Hadi, Sanjeev, Suvansh, Schwarzer, Max, Sculley, D., Sikchi, Harshit, Simon, Kendal, Singhal, Karan, Song, Yang, Stuckey, Dane, Sun, Zhiqing, Tillet, Philippe, Toizer, Sam, Tsimpourlas, Foivos, Vyas, Nikhil, Wallace, Eric, Wang, Xin, Wang, Miles, Watkins, Olivia, Weil, Kevin, Wendling, Amy, Whinnery, Kevin, Whitney, Cedric, Wong, Hannah, Yang, Lin, Yang, Yu, Yasunaga, Michihiro, Ying, Kristen, Zaremba, Wojciech, Zhan, Wenting, Zhang, Cyril, Zhang, Brian, Zhang, Eddie, Zhao, Shengjia   +125 more
openaire   +3 more sources

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Modern Russian-language texts models comparison for the task of CEFR levels classification

Моделирование и анализ информационных систем
The development of high-quality tools for automatic determination of text levels according to the CEFR scale allows creating educational and testing materials more quickly and objectively.
Vadim A. Lavrovskiy, Nadezhda S. Lagutina, Olga B. Lavrovskaya   +2 more
doaj   +1 more source