Results 1 to 10 of about 4,284 (136)

An In Vivo Mouse Model for Chronic Inflammation-Induced Immune Suppression: A "Factory" for Myeloid-Derived Suppressor Cells (MDSCs). [PDF]

Curr Protoc, 2022
Abstract Myeloid‐derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells known to play a role in perpetuating a wide range of pathologies, such as chronic infections, autoimmune diseases, and cancer. MDSCs were first identified in mice by the markers CD11b+Gr1+, and later, based on their morphology, they were ...
Ben-Meir K, Twaik N, Meirow Y, Baniyash M.   +3 more
europepmc   +2 more sources

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]

Proteoglycan Res
ABSTRACT Hyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions.
Queisser KA, Smith L, Leung G, Albtoush N, Mellema RA, Petrey AC.   +5 more
europepmc   +2 more sources

Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms. [PDF]

Cancer Sci, 2022
We demonstrate that manipulating the intrinsic apoptotic pathway may be an alternative strategy to treat MPN induced by JAK2V617F. Disrupting the BCL2 balance is not sufficient to treat MPN at the stem cell level, but it is certainly an option for controlling the myeloid expansion that leads to clinical complications dependent on increased cell counts ...
Takei H, Coelho-Silva JL, Tavares Leal C, Queiroz Arantes Rocha A, Mantello Bianco T, Welner RS, Mishima Y, Kobayashi IS, Mullally A, Lima K, Machado-Neto JA, Kobayashi SS, Lobo de Figueiredo-Pontes L.   +12 more
europepmc   +2 more sources

Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury. [PDF]

Adv Sci (Weinh), 2022
A new concept of “nano‐enabled drug repurposing” is proposed based on understanding the nanoparticle‐immune system interactions to empower the existing drugs for new uses. Herein, the proton pump inhibitors are identified to share similar mechanisms of action to bioactive gold nanoparticles with undiscovered Toll‐like receptor inhibitory and anti ...
Sun L, Liu Y, Liu X, Wang R, Gong J, Saferali A, Gao W, Ma A, Ma H, Turvey SE, Fung SY, Yang H.   +11 more
europepmc   +2 more sources

The Balkan Concept of the Phenomenon of Odessa Culture

Yearbook of Balkan and Baltic Studies, 2021
This article explores manifestations of the Balkan concept as a component of the phenomenon of ‘Odessa culture’. The research aims to reveal the concept’s specific components, how they were formed in Odessa’s sociocultural environment and how they are ...
Halyna Stoyanova
doaj   +1 more source

The Cross-Cultural Background and Modern Transformations of Religious and Spiritual Symbols of Lithuanian Identity

Yearbook of Balkan and Baltic Studies, 2021
Traditional symbols and codes are very powerful elements of culture. In modernity they have become connected with the paradigm of intertextuality: being actual because of their modern and contemporary treatment, at the same time they are associated with
Vytautas Tumėnas
doaj   +1 more source

National and Confessional Features of Festivals and Holidays: Structure of the Ritual Year in Modern Lithuania and Bulgaria

Yearbook of Balkan and Baltic Studies, 2021
The article aims to answer the question of whether different confessions and nationalities are an important factor in structuring a nation’s ritual year.
Žilvytis Šaknys
doaj   +1 more source

Introduction

Yearbook of Balkan and Baltic Studies, 2021
This edition of the Yearbook of Balkan and Baltic Studies focuses on discussion and ongoing research presented to an academic community of scholars in Balkan and Baltic Studies at a conference held on 9-11 June 2020 in Riga, Latvia, organized by the ...
Robert Parkin, Inese Runce
doaj   +1 more source

Modified Spatially Confined Strategy Enabled Mild Growth Kinetics for Facile Growth Management of Atomically‐Thin Tungsten Disulfides

Advanced Science, Volume 10, Issue 3, January 25, 2023., 2023
A modified spatially confined strategy create slow rising of S:W to maintain a mild growth kinetics of WS2, leading to the facile regulation of selective lateral/vertical growth. Referring to SW‐T diagram, the growth routes for 2D WS2 are facilely designed, leading to the versatile growth control of atomically thin WS2 on domain size, layer number, and
Qun Wang, Shi Wang, Jingyi Li, Yichen Gan, Mengtian Jin, Run Shi, Abbas Amini, Ning Wang, Chun Cheng   +8 more
wiley   +1 more source

A novel wearable free‐wideband antenna circularly polarized suited for biotelemetric devices with multiple‐input multiple‐output and high data rate capacity

The Journal of Engineering, Volume 2022, Issue 6, Page 595-607, June 2022., 2022
Abstract A small circularly polarized multiple‐input multiple‐output (MIMO) antenna is demonstrated here as a biometric gadget for consumers. In this article, the authors introduce a structure for antennas that consists of four essential parts that are orthogonally arranged opposite each other.
Pillalamarri Laxman, Anuj Jain
wiley   +1 more source