Results 11 to 20 of about 51,276 (180)
An In Vivo Mouse Model for Chronic Inflammation-Induced Immune Suppression: A "Factory" for Myeloid-Derived Suppressor Cells (MDSCs). [PDF]
Curr Protoc, 2022 Abstract Myeloid‐derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells known to play a role in perpetuating a wide range of pathologies, such as chronic infections, autoimmune diseases, and cancer. MDSCs were first identified in mice by the markers CD11b+Gr1+, and later, based on their morphology, they were ...
Ben-Meir K +3 more
europepmc +2 more sources
Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]
Proteoglycan ResABSTRACT Hyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions.
Queisser KA +5 more
europepmc +2 more sources
Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms. [PDF]
Cancer Sci, 2022 We demonstrate that manipulating the intrinsic apoptotic pathway may be an alternative strategy to treat MPN induced by JAK2V617F. Disrupting the BCL2 balance is not sufficient to treat MPN at the stem cell level, but it is certainly an option for controlling the myeloid expansion that leads to clinical complications dependent on increased cell counts ...
Takei H +12 more
europepmc +2 more sources
Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury. [PDF]
Adv Sci (Weinh), 2022 A new concept of “nano‐enabled drug repurposing” is proposed based on understanding the nanoparticle‐immune system interactions to empower the existing drugs for new uses. Herein, the proton pump inhibitors are identified to share similar mechanisms of action to bioactive gold nanoparticles with undiscovered Toll‐like receptor inhibitory and anti ...
Sun L +11 more
europepmc +2 more sources
Advanced Science, Volume 10, Issue 3, January 25, 2023., 2023 A modified spatially confined strategy create slow rising of S:W to maintain a mild growth kinetics of WS2, leading to the facile regulation of selective lateral/vertical growth. Referring to SW‐T diagram, the growth routes for 2D WS2 are facilely designed, leading to the versatile growth control of atomically thin WS2 on domain size, layer number, and
Qun Wang +8 more
wiley +1 more source
DCAF13 Safeguards Hematopoietic Stem Cells via RRS1-Regulated Ribosome Biogenesis. [PDF]
Adv Sci (Weinh)This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Li M +25 more
europepmc +2 more sources
The Journal of Engineering, Volume 2022, Issue 6, Page 595-607, June 2022., 2022 Abstract A small circularly polarized multiple‐input multiple‐output (MIMO) antenna is demonstrated here as a biometric gadget for consumers. In this article, the authors introduce a structure for antennas that consists of four essential parts that are orthogonally arranged opposite each other.
Pillalamarri Laxman, Anuj Jain
wiley +1 more source
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
European Journal of Immunology, Volume 51, Issue 12, Page 2708-3145, December 2021., 2021 Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets.
Andrea Cossarizza +192 more
wiley +1 more source
Charge‐Assisted Engineering of Color Centers in Diamond
physica status solidi (a), Volume 218, Issue 5, March 2021., 2021 The recently developed method of charge‐assisted single defect engineering is reviewed. Applying this method to color centers in diamond enables a strong enhancement of their creation while hindering formation of competing and perturbing defects. Furthermore, improved charge state stability and coherence times are obtained.
Tobias Lühmann +2 more
wiley +1 more source
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
White, Janice +11 more
core +1 more source