Results 11 to 20 of about 4,260 (116)

An In Vivo Mouse Model for Chronic Inflammation-Induced Immune Suppression: A "Factory" for Myeloid-Derived Suppressor Cells (MDSCs). [PDF]

Curr Protoc, 2022
Abstract Myeloid‐derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells known to play a role in perpetuating a wide range of pathologies, such as chronic infections, autoimmune diseases, and cancer. MDSCs were first identified in mice by the markers CD11b+Gr1+, and later, based on their morphology, they were ...
Ben-Meir K, Twaik N, Meirow Y, Baniyash M.   +3 more
europepmc   +2 more sources

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]

Proteoglycan Res
ABSTRACT Hyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions.
Queisser KA, Smith L, Leung G, Albtoush N, Mellema RA, Petrey AC.   +5 more
europepmc   +2 more sources

Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms. [PDF]

Cancer Sci, 2022
We demonstrate that manipulating the intrinsic apoptotic pathway may be an alternative strategy to treat MPN induced by JAK2V617F. Disrupting the BCL2 balance is not sufficient to treat MPN at the stem cell level, but it is certainly an option for controlling the myeloid expansion that leads to clinical complications dependent on increased cell counts ...
Takei H, Coelho-Silva JL, Tavares Leal C, Queiroz Arantes Rocha A, Mantello Bianco T, Welner RS, Mishima Y, Kobayashi IS, Mullally A, Lima K, Machado-Neto JA, Kobayashi SS, Lobo de Figueiredo-Pontes L.   +12 more
europepmc   +2 more sources

Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury. [PDF]

Adv Sci (Weinh), 2022
A new concept of “nano‐enabled drug repurposing” is proposed based on understanding the nanoparticle‐immune system interactions to empower the existing drugs for new uses. Herein, the proton pump inhibitors are identified to share similar mechanisms of action to bioactive gold nanoparticles with undiscovered Toll‐like receptor inhibitory and anti ...
Sun L, Liu Y, Liu X, Wang R, Gong J, Saferali A, Gao W, Ma A, Ma H, Turvey SE, Fung SY, Yang H.   +11 more
europepmc   +2 more sources

Modified Spatially Confined Strategy Enabled Mild Growth Kinetics for Facile Growth Management of Atomically‐Thin Tungsten Disulfides

Advanced Science, Volume 10, Issue 3, January 25, 2023., 2023
A modified spatially confined strategy create slow rising of S:W to maintain a mild growth kinetics of WS2, leading to the facile regulation of selective lateral/vertical growth. Referring to SW‐T diagram, the growth routes for 2D WS2 are facilely designed, leading to the versatile growth control of atomically thin WS2 on domain size, layer number, and
Qun Wang, Shi Wang, Jingyi Li, Yichen Gan, Mengtian Jin, Run Shi, Abbas Amini, Ning Wang, Chun Cheng   +8 more
wiley   +1 more source

A novel wearable free‐wideband antenna circularly polarized suited for biotelemetric devices with multiple‐input multiple‐output and high data rate capacity

The Journal of Engineering, Volume 2022, Issue 6, Page 595-607, June 2022., 2022
Abstract A small circularly polarized multiple‐input multiple‐output (MIMO) antenna is demonstrated here as a biometric gadget for consumers. In this article, the authors introduce a structure for antennas that consists of four essential parts that are orthogonally arranged opposite each other.
Pillalamarri Laxman, Anuj Jain
wiley   +1 more source

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

European Journal of Immunology, Volume 51, Issue 12, Page 2708-3145, December 2021., 2021
Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets.
Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Mübeccel Akdis, Immanuel Andrä, Francesco Andreata, Francesco Annunziato, Eduardo Arranz, Petra Bacher, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Dirk Baumjohann, Cristian G. Beccaria, David Bernardo, Dominic A. Boardman, Jessica Borger, Chotima Böttcher, Leonie Brockmann, Marie Burns, Dirk H. Busch, Garth Cameron, Ilenia Cammarata, Antonino Cassotta, Yinshui Chang, Fernando Gabriel Chirdo, Eleni Christakou, Luka Čičin‐Šain, Laura Cook, Alexandra J. Corbett, Rebecca Cornelis, Lorenzo Cosmi, Martin S. Davey, Sara De Biasi, Gabriele De Simone, Genny del Zotto, Michael Delacher, Francesca Di Rosa, James Di Santo, Andreas Diefenbach, Jun Dong, Thomas Dörner, Regine J. Dress, Charles‐Antoine Dutertre, Sidonia B. G. Eckle, Pascale Eede, Maximilien Evrard, Christine S. Falk, Markus Feuerer, Simon Fillatreau, Aida Fiz‐Lopez, Marie Follo, Gemma A. Foulds, Julia Fröbel, Nicola Gagliani, Giovanni Galletti, Anastasia Gangaev, Natalio Garbi, José Antonio Garrote, Jens Geginat, Nicholas A. Gherardin, Lara Gibellini, Florent Ginhoux, Dale I. Godfrey, Paola Gruarin, Claudia Haftmann, Leo Hansmann, Christopher M. Harpur, Adrian C. Hayday, Guido Heine, Daniela Carolina Hernández, Martin Herrmann, Oliver Hoelsken, Qing Huang, Samuel Huber, Johanna E. Huber, Jochen Huehn, Michael Hundemer, William Y. K. Hwang, Matteo Iannacone, Sabine M. Ivison, Hans‐Martin Jäck, Peter K. Jani, Baerbel Keller, Nina Kessler, Steven Ketelaars, Laura Knop, Jasmin Knopf, Hui‐Fern Koay, Katja Kobow, Katharina Kriegsmann, H. Kristyanto, Andreas Krueger, Jenny F. Kuehne, Heike Kunze‐Schumacher, Pia Kvistborg, Immanuel Kwok, Daniela Latorre, Daniel Lenz, Megan K. Levings, Andreia C. Lino, Francesco Liotta, Heather M. Long, Enrico Lugli, Katherine N. MacDonald, Laura Maggi, Mala K. Maini, Florian Mair, Calin Manta, Rudolf Armin Manz, Mir‐Farzin Mashreghi, Alessio Mazzoni, James McCluskey, Henrik E. Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Leticia Monin, Lorenzo Moretta, Gabriele Multhoff, Luis Enrique Muñoz, Miguel Muñoz‐Ruiz, Franziska Muscate, Ambra Natalini, Katrin Neumann, Lai Guan Ng, Antonia Niedobitek, Jana Niemz, Larissa Nogueira Almeida, Samuele Notarbartolo, Lennard Ostendorf, Laura J. Pallett, Amit A. Patel, Gulce Itir Percin, Giovanna Peruzzi, Marcello Pinti, A. Graham Pockley, Katharina Pracht, Immo Prinz, Irma Pujol‐Autonell, Nadia Pulvirenti, Linda Quatrini, Kylie M. Quinn, Helena Radbruch, Hefin Rhys, Maria B. Rodrigo, Chiara Romagnani, Carina Saggau, Shimon Sakaguchi, Federica Sallusto, Lieke Sanderink, Inga Sandrock, Christine Schauer, Alexander Scheffold, Hans U. Scherer, Matthias Schiemann, Frank A. Schildberg, Kilian Schober, Janina Schoen, Wolfgang Schuh, Thomas Schüler, Axel R. Schulz, Sebastian Schulz, Julia Schulze, Sonia Simonetti, Jeeshan Singh, Katarzyna M. Sitnik, Regina Stark, Sarah Starossom, Christina Stehle, Franziska Szelinski, Leonard Tan, Attila Tarnok, Julia Tornack, Timothy I. M. Tree, Jasper J. P. van Beek, Willem van de Veen, Klaas van Gisbergen, Chiara Vasco, Nikita A. Verheyden, Anouk von Borstel, Kirsten A. Ward‐Hartstonge, Klaus Warnatz, Claudia Waskow, Annika Wiedemann, Anneke Wilharm, James Wing, Oliver Wirz, Jens Wittner, Jennie H. M. Yang, Juhao Yang   +192 more
wiley   +1 more source

Charge‐Assisted Engineering of Color Centers in Diamond

physica status solidi (a), Volume 218, Issue 5, March 2021., 2021
The recently developed method of charge‐assisted single defect engineering is reviewed. Applying this method to color centers in diamond enables a strong enhancement of their creation while hindering formation of competing and perturbing defects. Furthermore, improved charge state stability and coherence times are obtained.
Tobias Lühmann, Jan Meijer, Sébastien Pezzagna   +2 more
wiley   +1 more source

Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

STEM CELLS, Volume 39, Issue 2, Page 240-252, February 2021., 2021
Sirolimus accelerates hematopoietic stem and progenitor cell recovery in response to hematopoietic stress, which is associated with reduced DNA damage and reactive oxygen species. Abstract The role of mammalian target of rapamycin and its suppressor sirolimus in the regulation of hematopoietic stem and progenitor cells (HSPCs) is controversial. We show
Zenghua Lin, Maile K. Hollinger, Zhijie Wu, Wanling Sun, Kaylind Batey, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young   +8 more
wiley   +1 more source

The Ecological Funeral: New Ideas in Contemporary Lithuania

Yearbook of Balkan and Baltic Studies, 2023
The article examines ecological funerals in contemporary Lithuania. The present study focuses on content and visual analysis of funeral celebrations taking information from the contemporary Lithuanian mass media and social media networks, as well as the ...
Rasa Račiūnaitė-Paužuolienė
doaj   +1 more source