Results 31 to 40 of about 44,021 (265)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Polazišta održivoga prostornog razvoja grada

Prostor, 2001
Promjene okoliša rezultat su načina na koji živimo i koristimo prostor. Svi korisnici prostora moraju postati svjesni ekološke odgovornosti. Ne možemo očekivati da ćemo sve probleme okoliša moći riješiti tehnologijom.
Srečko Pegan, Tihomir Jukić
doaj  

Neizbježnost aporije u pokušaju definiranja znanja u Platonovim dijalozima Teetet i Fedon, te o logosu i o znanstvenosti teologije

Nova Prisutnost, 2022
Ovaj članak želi pokazati kako su se sudionici u dijalogu Teetet složili da je znanje (ἐπιστήμη) ‘istinito mišljenje (sgr. δόξα) spojeno s objašnjenjem’ (λόγος) (201d), ali da nisu uspjeli protumačiti što je logos te da je taj pokušaj definiranja znanja ...
Josip Balabanić
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Serial assessment of inflammatory biomarkers as a prognostic factor for first-line treatment outcomes in patients with metastatic colorectal cancer: single-center retrospective study

Frontiers in Oncology
BackgroundMetastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality, with limited curative options despite advances in targeted therapies. Reliable prognostic biomarkers are needed to guide treatment.
Nikša Librenjak, Gordan Adžić, Domina Kekez, Domina Kekez, Irma Goršić, Juraj Prejac, Juraj Prejac, Stjepko Pleština, Stjepko Pleština   +8 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Urbana rasprava ususret Zagrebu XXI. stoljeća

Prostor, 1998
Grad se u članku promatra kao moždano tkivo prostora i njegove se odlike suprotstavljaju kritikama urbanih koncentracija. Grad ostaje kolijevka budućnosti civilizacije.
Velimir Neidhardt
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