Results 41 to 50 of about 44,021 (265)

Concepções e práticas do trabalho e gestão de equipes multidisciplinares em saúde

Revista de Ciências da Administração : RCA, 2012
Este trabalho trata do seguinte objetivo: conhecer as concepções e a prática de trabalho em equipe multidisciplinar sob a ótica dos gestores e dos membros das equipes.
Lucimara Alves Silva, Jair Nascimento Santos   +1 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Utjecaj procesa globalizacije na planiranje prostora

Prostor, 2006
Zahvaljujući utjecaju globalizacije i restrukturiranju gradova i regija, pitanja oko urbanoga i regionalnoga razvoja postala su dio stručne, ali i političke rasprave.
Sanja Šaban
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Parkovna arhitektura kao element slike grada

Prostor, 1996
Sustav prometnica i ulica, struktura i tipologija izgradnje te parkovno oblikovanje tri su bitna elementa u stvaranju prepoznatljivosti i slike grada. U članku se upozorava na značenje parkovne arhitekture u oblikovanju urbanog identiteta.
Mladen Obad Šćitaroci, Bojana Bojanić Obad Šćitaroci   +1 more
doaj  

“Osobni dosjei” vile Frangeš i vile Peroš prije i nakon potresa 2020. godine u Zagrebu

Radovi Instituta za Povijest Umjetnosti, 2020
Na primjeru dviju vila građenih početkom 20. stoljeća, vile Frangeš, pojedinačno zaštićenoga kulturnog dobra, i vile Peroš, koja predstavlja ambijentalnu vrijednost Povijesne urbane cjeline Grad Zagreb, autorice iznose problematiku njihove zaštite i ...
Nina Gazivoda, Marijana Sironić
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Enhancement of Optical Nonlinearity in Coupled Resonator Optical Waveguide Based on Slotted 1-D Photonic Crystal Cavity

IEEE Photonics Journal, 2015
A coupled resonator optical waveguide (CROW) based on a slotted 1-D photonic crystal (1-D PC) cavity is proposed, and its enhancement of the optical nonlinearity due to the slow-light effect of the CROW and the small effective area of the slotted 1-D PC ...
Shuntaro Makino, Takeshi Fujisawa, Kunimasa Saitoh   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source