Results 51 to 60 of about 30,006 (292)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Network diversity structure, closeness and innovation of South African micro-entrepreneurs
South African Journal of Economic and Management Sciences, 2014 This study qualitatively explores the embeddedness of the innovation process of South African microbusinesses by investigating how small local entrepreneurs in the Greater Johannesburg area utilise their social networks to source entrepreneurial value. A
Eliada Wosu Griffin-EL
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Mixing Enhancement and Interface Characteristics in a Small-Scale Channel
Journal of Fluid Science and Technology, 2008 The interface characteristics in a millimeter-scale channel are investigated in order to find a technique to speed up fluid mixing. The channel is fabricated on an acrylic-resin plate, where a cavity is attached in the downstream region of a T-shaped ...
Shuta NORO +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Improving the Yield of Glucoamylase and α-amylase in Solid-state Co-culture
MATEC Web of Conferences, 2016 Steamed rice inoculated with Aspergillus oryzae, called Koji, is an essential ingredient for making amazake or brewing sake. However, A. oryzae usually offers low enzyme yield, especially in case of glucoamylase.
Takefuji Haruka +2 more
doaj +1 more source
Barn, 2023 Der tilbydes i stigende grad samtalegrupper for børn og unge på danske skoler, hvor interventionen ledes af enten lærere og pædagoger. Interventionen tilbydes til børn og unge i sorg på grund af dødsfald i familien, eller hvis forældre bliver skilt ...
Pernelle Rose, Anne Suhr
doaj +1 more source
, 2022 In Doing Economics: What You Should Have Learned in Grad School – But Didn’t, Marc F. Bellemare offers a new guide to research economists to help equip them with the practical tools for ‘doing economics’. This book will be an excellent starting point for
Patgiri, Ritwika
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source