Results 31 to 40 of about 42,938 (206)
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
On the last Hilbert-Samuel coefficient of isolated singularities [PDF]
, 2010 In 1978 Lipman presented a proof of the existence of a desingularization for any excellent surface. The strategy of Lipman's proof is based on the finiteness of the number H(R) defined as the supreme of the second Hilbert-Samuel coefficient I, where I ...
Elias, Juan
core
Multiplicity bounds in graded rings
, 2010 The $F$-threshold $c^J(\a)$ of an ideal $\a$ with respect to an ideal $J$ is a positive characteristic invariant obtained by comparing the powers of $\a$ with the Frobenius powers of $J$.
Huneke, Craig +2 more
core +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Multiplicities Associated to Graded Families of Ideals
, 2013 We prove that limits of multiplicities associated to graded families of ideals exist under very general conditions. Most of our results hold for analytically unramified equicharacteristic local rings, with perfect residue fields.
Cutkosky, Steven Dale
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A Note on Formulas Transmuting Mixed Multiplicities
, 2012 This paper establishes mixed multiplicity formulas concerning the relationship between mixed multiplicities of modules and mixed multiplicities of rings via rank of ...
Thanh, Truong Thi Hong, Viet, Duong Quoc
core +1 more source
Primary ideals with good associated graded ring
Journal of Pure and Applied Algebra, 2000 Let \((A,{\mathcal M})\) be a local Cohen-Macaulay ring of dimension \(d>0\), let \(I\) be an \({\mathcal M}\)-primary ideal of \(A\), \(J\) be the ideal generated by a maximal superficial sequence for \(I\), and let \(G\) be the associated graded ring of \(I\). For a natural number \(k\), the ideal \(I\) is said to be \(k\)-standard if \(I^n\cap J=JI^{
openaire +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source