Results 111 to 120 of about 23,928,830 (244)

Gradient vs. Non-Gradient-Based Model Free Control Algorithms: Analysis and Applications to Nonlinear Systems

open access: yesApplied Sciences
Against the background of the development of control systems, Data Driven Control (DDC) methods are becoming more and more popular, given the system’s independence from physical models and the possibility of quickly tuning the controller.
Andrei Baciu, Corneliu Lazar
doaj   +1 more source

Critical time scales for morphogen gradient formation: Concentration or gradient criteria?

open access: yes, 2017
Highlights\ud \ud - Investigate time for morphogen gradient to effectively reach steady state.\ud \ud - Analyse both the concentration profile and the gradient of the concentration profile.\ud \ud - For typical problem, the gradient effectively ...
Simpson, Matthew
core   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Influencia de factores ambientales en la distribución de especies arbóreas en las selvas del sureste de México

open access: yesRevista de Biología Tropical, 2005
Se estableció la relación entre la distribución de las especies arbóreas de la selva mediana y baja y los factores edáficos y microtopográficos en la Reserva de la Biosfera de Sian Ka’an.
José C Cortés-Castelán   +1 more
doaj  

Figure 2: Path-Gradient-Planning - Situational Gradient Norms

open access: yes
Path-Gradient Norms for Grid-world environments show in Figure 1.E-OEach frame represents the heat-map of gradient norms for each state over training steps. Gradients were computed using Path-Gradient Planning with situational focus.
Francesco Trapani (16642515)
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

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