Results 91 to 100 of about 23,928,830 (244)

Investigation of sound propagation in a duct with a mean temperature gradient [PDF]

open access: yes, 2014
This paper presents an analytical and numerical investigation of an impedance tube in the presence of a mean temperature gradient. Full Navier-Stokes simulation of the acoustic wave propagations through an impedance tube in the presence of a mean ...
Aygun, Haydar
core  

Gradient design of metal hollow sphere (MHS) foams with density gradients [PDF]

open access: yes, 2012
This is the post-print version of the final paper published in Composites Part B: Engineering. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Liu, Y   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis on Variation Characteristics of Land-use Landscape Gradient in the Songnen High Plain

open access: yesShuitu baochi yanjiu, 2013
Study on the variation characteristics of regional different gradient zones of land-use landscape aimed at providing a scientific basis for the maintenance of regional ecological function and the improvement of regional ecological environment quality.The
SONG Ge, FU Jin-shan, WANG Yue
doaj  

Behaviour of acoustic waves in a duct with Helmholtz resonator in presence of a temperature gradient [PDF]

open access: yes, 2014
Understanding the behaviour of one-dimensional acoustical wave propagation in ducts is very important for controlling combustion instabilities in propulsion, household burners, gas turbine combustors, and designing engineering mufflers.
Haydar , Aygun, Aygun, Haydar
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Analysis on Vegetation-Environment Gradient Correlation in Qinling Mountain Based on GIS

open access: yesShuitu baochi yanjiu, 2009
Based on the relation of vegetation-environment,which is a hotspot in landscape ecology,geography information system technique was applied.The research gave a multi-analysis on vegetation in Qinling mountain,and the correlation of different types of ...
ZHU Xiao-qin1   +3 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Brain Myelin Covariance Networks: Gradients, Cognition, and Higher-Order Landscape

open access: yesBehavioral Sciences
Myelin is essential for efficient neural signaling and can be quantitatively evaluated using the T1-weighted/T2-weighted (T1w/T2w) ratio as a proxy for regional myelin content.
Huijun Wu   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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