Results 81 to 90 of about 23,928,830 (244)

A method for improving the performance of gradient systems for diffusion-weighted MRI [PDF]

open access: yes, 2007
The MR signal is sensitive to diffusion. This effect can be increased by the use of large, balanced bipolar gradients. The gradient systems of MR scanners are calibrated at installation and during regular servicing visits.
Daniel C. Alex   +11 more
core   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Sentiment Analysis Combining Dynamic Gradient and Multi-view Co-attention [PDF]

open access: yesJisuanji kexue yu tansuo
Aiming at the problems of unbalanced inter-modal optimization and inadequate fusion of multimodal features in multimodal sentiment analysis, a multimodal sentiment analysis model combining dynamic gradient mechanism and multi-view co-attention mechanism (
WANG Xiang, MAO Li, CHEN Qidong, SUN Jun
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

marcocintra/Gradient-Spectral-Analysis 1.0.0

open access: yes, 2019
Principais softwares e dados utilizados no desenvolvimento da dissertação de Cintra ...
Marco Antônio de Ulhôa Cintra
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Analysis of Gradient Waveform in Magnetic Resonance Imaging

open access: yesChinese Journal of Magnetic Resonance, 2017
The accuracy of gradient pulse waveform affects image quality significantly in magnetic resonance imaging (MRI). Recording and analyzing the waveform of gradient pulse helps to make rapid and accurate diagnosis of spectrometer gradient hardware and/or ...
OU-YANG Shan-mei, LOU Yu-kun, XIAO Liang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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