Results 51 to 60 of about 2,990,696 (280)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Spectral Adaptive Dropout: Frequency-Based Regularization for Improved Generalization

open access: yesInformation
Deep neural networks are often susceptible to overfitting, necessitating effective regularization techniques. This paper introduces Spectral Adaptive Dropout, a novel frequency-based regularization technique that dynamically adjusts dropout rates based ...
Zhigao Huang, Musheng Chen, Shiyan Zheng
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Vegetation of the coastal fynbos and rocky headlands south of George, South Africa

open access: yesBothalia: African Biodiversity & Conservation, 2000
Community structure and composition of the coastal fynbos and rocky headland plant communities south of George, southern Cape, were studied. Vegetation was analysed using standard sampling procedures of the floristic-sociological approach of Braun ...
D. B. Hoare, J. E. Victor, R. A. Lubke
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Global Biogeographical Pattern of Ecosystem Functional Types Derived From Earth Observation Data

open access: yesRemote Sensing, 2013
The present study classified global Ecosystem Functional Types (EFTs) derived from seasonal vegetation dynamics of the GIMMS3g NDVI time-series. Rotated Principal Component Analysis (PCA) was run on the derived phenological and productivity variables ...
Rasmus Fensholt   +3 more
doaj   +1 more source

Hybrid Deterministic-Stochastic Methods for Data Fitting

open access: yes, 2011
Many structured data-fitting applications require the solution of an optimization problem involving a sum over a potentially large number of measurements.
Kumar S.   +5 more
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Soil Nutrients in Sandy Plantations Are Related to the Species, Diameter at Breast Height or at Base, and Distance from the Tree Base in Horqin

open access: yesLand
Correctly understanding existing plantations and improving the cycles and effects of ecological restoration in sandy areas have become important scientific issues. Consequently, we selected different diameters at breast height (DBHs) for Populus spp. and
Hongshun Liu   +6 more
doaj   +1 more source

Local and Regional Scale Heterogeneity Drive Bacterial Community Diversity and Composition in a Polar Desert

open access: yesFrontiers in Microbiology, 2018
The distribution of organisms in an environment is neither uniform nor random but is instead spatially patterned. The factors that control this patterning are complex and the underlying mechanisms are poorly understood.
Kelli L. Feeser   +7 more
doaj   +1 more source

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