Results 121 to 130 of about 36,010,976 (311)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshuShape design optimization of 3-dimensional solid structures must satisfy two key objectives: high mechanical performance and light weight. For machines in motion, time-response problems in design optimization are crucial for machine life and reliability,
Haruki IGAWA, Jin-Xing SHI
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Gradient Method with Step Adaptation
MathematicsThe paper solves the problem of constructing step adjustment algorithms for a gradient method based on the principle of the steepest descent. The expansion of the step adjustment principle, its formalization and parameterization led the researchers to ...
Vladimir Krutikov +4 more
doaj +1 more source
Sparse identification of Lagrangian for nonlinear dynamical systems via proximal gradient method. [PDF]
Sci Rep, 2023 Purnomo A, Hayashibe M.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
On the Relative Efficiencies of Gradient Methods [PDF]
Mathematics of Computation, 1967 A comparison is made among various gradient methods for maximizing a function, based on a characterization by Crockett and Chernoff of the class of these methods. By defining the “efficiency” of a gradient step in a certain way, it becomes easy to compare the efficiencies of different schemes with that of Newton’s method, which can be regarded as a ...
openaire +2 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A modified secant method for unconstrained minimization [PDF]
A gradient-secant algorithm for unconstrained optimization problems is presented. The algorithm uses Armijo gradient method iterations until it reaches a region where the Newton method is more efficient, and then switches over to a secant form of ...
Polak, E.
core +1 more source