Results 41 to 50 of about 286,034 (261)

Dislocation microstructures and strain-gradient plasticity with one active slip plane

, 2015
We study dislocation networks in the plane using the vectorial phase-field model introduced by Ortiz and coworkers, in the limit of small lattice spacing.
Conti, Sergio, Garroni, Adriana, Müller, Stefan   +2 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Assumed-strain finite element technique for accurate modelling of plasticity problems [PDF]

, 2013
In this work a linear hexahedral element based on an assumed-strain finite element technique is presented for the solution of plasticity problems. The element stems from the NICE formulation and its extensions.
Artioli, E., Castellazzi, G., Krysl, P.
core  

Strain Gradient Plasticity: Theory and Implementation

, 2020
This chapter focuses on the foundation and development of various higher-order strain gradient plasticity theories, and it also provides the basic elements for their finite element implementation. To this aim, we first refer to experiments exhibiting size-effects in metals and explain them by resorting to the concept of geometrically necessary ...
Lorenzo Bardella, Christian F. Niordson
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Dissipative scale effects in strain-gradient plasticity: the case of simple shear

, 2015
We analyze dissipative scale effects within a one-dimensional theory, developed in [L. Anand et al. (2005) J. Mech. Phys. Solids 53], which describes plastic flow in a thin strip undergoing simple shear.
Chiricotto, Maria, Giacomelli, Lorenzo, Tomassetti, Giuseppe   +2 more
core   +1 more source

A finite element framework for distortion gradient plasticity with applications to bending of thin foils [PDF]

International Journal of Solids and Structures 96, pp. 288-299 (2016), 2017
A novel general purpose Finite Element framework is presented to study small-scale metal plasticity. A distinct feature of the adopted distortion gradient plasticity formulation, with respect to strain gradient plasticity theories, is the constitutive inclusion of the plastic spin, as proposed by Gurtin (2004) through the prescription of a free energy ...
arxiv   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Korn's second inequality and geometric rigidity with mixed growth conditions

, 2012
Geometric rigidity states that a gradient field which is $L^p$-close to the set of proper rotations is necessarily $L^p$-close to a fixed rotation, and is one key estimate in nonlinear elasticity.
A Korn, A Korn, F John, G Friesecke, G Friesecke, Georg Dolzmann, I Hlaváček, J Gobert, J Peetre, JA Nitsche, JG Rešetnjak, JG Rešetnjak, JG Rešetnjak, KO Friedrichs, KT Smith, L Scardia, RA Hunt, RV Kohn, S Conti, Sergio Conti, Stefan Müller, V Agostiniani   +21 more
core   +1 more source