Results 41 to 50 of about 88,232 (305)

Research on transition layer microstructure and properties of Al–Cu/Al–Si gradient materials fabricated by cold metal transfer

open access: yesJournal of Materials Research and Technology, 2023
As an important part of the additive manufacturing technology, wire arc additive manufacture (WAAM) is outstanding with high deposition efficiency, large size of deposited parts, short periodic time, and low costs.
Jin Xinyuan   +7 more
doaj   +1 more source

The Flow Theory of Mechanism-Based Strain Gradient Plasticity

open access: yes, 2003
The flow theory of mechanism-based strain gradient (MSG) plasticity is established in this paper following the same multiscale, hierarchical framework for the deformation theory of MSG plasticity in order to connect with the Taylor model in dislocation ...
Hwang KC   +5 more
core   +1 more source

An approach to nonlinear viscoelasticity via metric gradient flows [PDF]

open access: yes, 2013
We formulate quasistatic nonlinear finite-strain viscoelasticity of rate type as a gradient system. Our focus is on nonlinear dissipation functionals and distances that are related to metrics on weak diffeomorphisms and that ensure time-dependent frame ...
Mielke, A.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

On the application of strain gradient crystal plasticity to study strain localization phenomena in single crystals [PDF]

open access: yes, 2021
Strain localization is an important plastic instability process occurring prior to fracture. It is usually observed in the form of narrow bands of intense plastic shear strain in deformed bodies undergoing severe inhomogeneous deformation.
CAI, Lei   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

pieterarnold/Patterns-of-plasticity: Data from: Patterns of phenotypic plasticity along a thermal gradient differ by trait type in an alpine plant

open access: yes, 2022
Data files and R code for analyses and figures associated with the Functional Ecology publication: "Patterns of phenotypic plasticity along a thermal gradient differ by trait type in an alpine plant"
Pieter Arnold
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Anterior-posterior gradient of plasticity in primate prefrontal cortex

open access: yesNature Communications, 2018
Studies of the functional organization of the prefrontal cortex have produced contradicting results depending on the task used. Here, Riley and colleagues demonstrate that prefrontal areas are specialized across the anterior posterior axis and that the ...
Mitchell R. Riley   +3 more
doaj   +1 more source

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