Results 91 to 100 of about 2,146,103 (291)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tailoring the gradient ultrafine-grained structure in low-carbon steel during drawing with shear
Metalurgija, 2016 Conventional drawing and drawing with shear were conducted on the rods of low-carbon steel. Deformation by simple drawing forms basically a homogenous structure and leads to a uniform change in microhardness along the billet volume.
G. I. Raab +2 more
doaj
Structure and Tensile Strength of Pure Cu after High Pressure Torsion Extrusion
Metals, 2019 The microstructure and mechanical properties of rod-shaped samples (measuring 11.8 mm in diameter and 35 mm in length) of commercially pure (CP) copper were characterized after they were processed by high pressure torsion extrusion (HPTE).
Dayan Nugmanov +3 more
doaj +1 more source
Gradient and Passive Circuit Structure in a Class of Non-linear Dynamics on a Graph
, 2016 We consider a class of non-linear dynamics on a graph that contains and generalizes various models from network systems and control and study convergence to uniform agreement states using gradient methods.
Acebrón +41 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
A gradient flow approach to the Boltzmann equation
, 2019 We show that the spatially homogeneous Boltzmann equation evolves as the gradient flow of the entropy with respect to a suitable geometry on the space of probability measures which takes the collision process into account.
Erbar, Matthias
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Успехи физики металловNowadays, emerging of new technologies causes implicitly the increased requirements for conventional methods and materials. Literature survey shows that combined thermomechanical processes of surface hardening and finishing using highly-concentrated ...
D.A. Lesyk, B.M. Mordyuk, W. Alnusirat, S. Martinez, V.V. Dzhemelinskyi, O.O. Honcharuk, P.V. Kondrashev, Yu.V. Kliuchnykov, and A. Lamikiz
doaj +1 more source