Results 111 to 120 of about 749,068 (264)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Ultrasonic Surface Finishing of AISI 1045 Steel Hardened by Laser Heat Treatment with Fibre Laser and Scanning Optics: Layered-Structure-Induced Hardening and Enhanced Surface Morphology

Успехи физики металлов
Nowadays, emerging of new technologies causes implicitly the increased requirements for conventional methods and materials. Literature survey shows that combined thermomechanical processes of surface hardening and finishing using highly-concentrated ...
D.A. Lesyk, B.M. Mordyuk, W. Alnusirat, S. Martinez, V.V. Dzhemelinskyi, O.O. Honcharuk, P.V. Kondrashev, Yu.V. Kliuchnykov, and A. Lamikiz
doaj   +1 more source

Extremely fast-charging lithium ion battery enabled by dual-gradient structure design. [PDF]

Sci Adv, 2022
Lu LL, Lu YY, Zhu ZX, Shao JX, Yao HB, Wang S, Zhang TW, Ni Y, Wang XX, Yu SH.   +9 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Fabrication and mechanical properties of gradient-structured W–Ni–Fe–Mo/Co tungsten heavy alloys

Fenmo yejin jishu
Gradient-structured tungsten heavy alloys with spatially graded mechanical properties can effectively resolve the strength-ductility trade-off in conventional homogeneous tungsten alloys. The high-strength 93W–Ni–Fe–Mo alloys and high-ductility 90W–Ni–Fe–
MENG Ziqi, DUAN Youteng, LIU Wensheng, MA Yunzhu, WU Tianhao, HAN Yifan, CAI Qingshan   +6 more
doaj   +1 more source

Path Generation Strategy and Wire Arc Additive Manufacturing of Large Aviation Die with Complex Gradient Structure. [PDF]

Materials (Basel), 2022
Zhang J, Xiao G, Peng J, Yu Y, Zhou J.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Exceptional mechanical properties of (Ti1−xZrx)2AlC MAX phase coatings with amorphous-nanocrystalline oxidation layers

Journal of Advanced Ceramics
The brittleness of hard ceramic materials poses a significant challenge to their practical application because of the trade-off between hardness and toughness. Here, we propose a hierarchical structure strategy that utilizes alloying and vacuum oxidation
Kaihang Wang, Yan Zhang, Guanshui Ma, Yuxi Xu, Zhenyu Wang, Aiying Wang   +5 more
doaj   +1 more source

Effect of Cold Swaging on the Bulk Gradient Structure Formation and Mechanical Properties of a 316-Type Austenitic Stainless Steel. [PDF]

Materials (Basel), 2022
Panov D, Chernichenko R, Kudryavtsev E, Klimenko D, Naumov S, Pertcev A.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source