Results 61 to 70 of about 749,068 (264)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

Metals, 2018
Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular bone.
Ezgi Onal, Jessica E. Frith, Marten Jurg, Xinhua Wu, Andrey Molotnikov   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mechanical and Corrosion Properties of AA2024 Aluminum Alloy with Multimodal Gradient Structures

Metals
Enhancing the strength and toughness of aluminum alloys using microstructure optimization remains a key challenge. In this study, an AA2024 aluminum alloy with a double-layer multi-gradient structure was fabricated using 50% constrained deformation and ...
Zhenwei Xie, Liexing Zhou, Jun Li, Yonghua Duan, Mingjun Peng, Hongbo Xiao, Xiong Du, Yuanjie Zhao, Mengnie Li   +8 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Investigating sound insulation performance of gradient airflow resistivity porous materials

Acta Acustica
The sound insulation performance of porous materials with gradient airflow resistivity is investigated using a combined approach based on the Johnson–Champoux–Allard (JCA) model and the Virtual Transmission Loss (VTL) method.
Zhu Keyi, Cheng Yuxiang, Xiong Xinzhong, Liu Xuewen   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effects of Nitrogen Partial Pressure on the Microstructure and Mechanical Properties of High-Entropy Ti(C,N)-Based Gradient Cermets

Crystals
Titanium carbonitride (Ti(C,N))-based ceramics are widely utilized in mechanical machining, aerospace, and electronics, particularly in cutting tools and wear-resistant components.
Yunhao Zhang, Houan Zhang, Dongxu Qiao, Xin Tao, Peng Xia, Siyong Gu   +5 more
doaj   +1 more source

Preparation and research of structure-gradient and corrosion-resistant aluminium coatings on steel surface

Cailiao gongcheng, 2019
In order to control the composition and microstructure of corrosion-resistant aluminum coatings, a layer of pre-coating was deposited on Q235 steel surface by magnetron sputtering, and then corrosion-resistant aluminum coating with a certain thickness ...
WANG Yao, ZHAO Xue-ni, DANG Xin-an, YANG Pu, WEI Sen-sen, ZHANG Wei-gang, LIU Qing-yao   +6 more
doaj   +1 more source