Results 71 to 80 of about 2,146,103 (291)

Mesoscale structural gradients in human tooth enamel

Proceedings of the National Academy of Sciences, 2022
The outstanding mechanical and chemical properties of dental enamel emerge from its complex hierarchical architecture. An accurate, detailed multiscale model of the structure and composition of enamel is important for understanding lesion formation in tooth decay (dental caries), enamel development (amelogenesis) and associated pathologies
Robert Free, Karen DeRocher, Victoria Cooley, Ruqing Xu, Stuart R. Stock, Derk Joester   +5 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modeling of extra strengthening in gradient nanotwinned metals based on molecular dynamics

Frontiers in Materials, 2022
Gradient nanotwinned metals exhibit extra strengthening and work hardening behaviors, which have enormous potential for engineering applications. In this study, molecular dynamics method is performed for analyzing the effects of nanotwinned structure ...
Zailin Yang, Zailin Yang, Xiaoyang Ding, Yong Yang, Yong Yang, Minghe Li, Shihao Cao   +6 more
doaj   +1 more source

Optimising continuous microstructures: a comparison of gradient-based and stochastic methods [PDF]

, 2004
This work compares the use of a deterministic gradient based search with a stochastic genetic algorithm to optimise the geometry of a space frame structure.
Hanna, S., Haroun Mahdavi, S.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mechanical and Corrosion Properties of AA2024 Aluminum Alloy with Multimodal Gradient Structures

Metals
Enhancing the strength and toughness of aluminum alloys using microstructure optimization remains a key challenge. In this study, an AA2024 aluminum alloy with a double-layer multi-gradient structure was fabricated using 50% constrained deformation and ...
Zhenwei Xie, Liexing Zhou, Jun Li, Yonghua Duan, Mingjun Peng, Hongbo Xiao, Xiong Du, Yuanjie Zhao, Mengnie Li   +8 more
doaj   +1 more source

Optimization of synchronization in gradient clustered networks

, 2007
We consider complex clustered networks with a gradient structure, where sizes of the clusters are distributed unevenly. Such networks describe more closely actual networks in biophysical systems and in technological applications than previous models ...
Choy Heng Lai, Liang Huang, S. Strogatz, T. Ideker, Xingang Wang, Ying-Cheng Lai   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Macroscopic limit of the Becker-D\"oring equation via gradient flows

, 2018
This work considers gradient structures for the Becker-D\"oring equation and its macroscopic limits. The result of Niethammer [17] is extended to prove the convergence not only for solutions of the Becker-D\"oring equation towards the Lifshitz-Slyozov ...
Schlichting, André
core   +1 more source