Results 81 to 90 of about 2,146,103 (291)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Non-Uniform Stochastic Average Gradient Method for Training Conditional Random Fields [PDF]

, 2015
We apply stochastic average gradient (SAG) algorithms for training conditional random fields (CRFs). We describe a practical implementation that uses structure in the CRF gradient to reduce the memory requirement of this linearly-convergent stochastic ...
Ahmed, Mohamed Osama, Babanezhad, Reza, Clifton, Ann, Defazio, Aaron, Sarkar, Anoop, Schmidt, Mark   +5 more
core  

Reflection of short polarized optical pulses from periodic and aperiodic multiple quantum well structures

, 2012
We study the reflection of polarized optical pulses from resonant photonic structures formed by periodic, Fibonacci, and gradient sequences of quantum wells.
Poddubny, A. N., Poshakinskiy, A. V., Tarasenko, S. A.   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Optimization in Gradient Networks

, 2007
Gradient networks can be used to model the dominant structure of complex networks. Previous works have focused on random gradient networks. Here we study gradient networks that minimize jamming on substrate networks with scale-free and Erd\H{o}s-R\'enyi ...
Gould H., Natali Gulbahce, Newman M. E. J., Newman M. E. J.   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Compositionally gradient Al2O3–B4C/Al composites with interpenetrating structure and tailored properties via material extrusion-based additive manufacturing and pressure infiltration

Virtual and Physical Prototyping
Traditional fabrication methods for metal–ceramic composites often struggle to achieve the level of control needed for material on-demand design and property optimisation, despite the potential for enhanced performance.
Yu-Bai Hu, Ming-Yue Jiang, Ping Shen
doaj   +1 more source

Hydrodynamics Beyond the Gradient Expansion: Resurgence and Resummation

, 2015
Consistent formulations of relativistic viscous hydrodynamics involve short lived modes, leading to asymptotic rather than convergent gradient expansions.
Heller, Michal P., Spalinski, Michal
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Bivariate Beta-LSTM

, 2019
Long Short-Term Memory (LSTM) infers the long term dependency through a cell state maintained by the input and the forget gate structures, which models a gate output as a value in [0,1] through a sigmoid function.
Jang, JoonHo, Moon, Il-Chul, Shin, Seung jae, Song, Kyungwoo   +3 more
core   +1 more source