Results 91 to 100 of about 1,379,799 (331)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
IEEE Transactions on Signal ProcessingDirectly parameterizing and learning gradients of functions has widespread significance, with specific applications in inverse problems, generative modeling, and optimal transport. This paper introduces gradient networks (GradNets): novel neural network architectures that parameterize gradients of various function classes.
Shreyas Chaudhari +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Método de optimización nonlineal adaptivo tipo simplex, utilizando flujo de gradientes
, 2015 Spa: Estamos presentando un método de optimización nolineal que representa una fusión de dos algoritmos más reconocidos del área: método de simplex y método de gradientes. Logramos de armar un método capaz de ajustar automáticamente su sensibilidad a los
Dulov, Eugene
core +2 more sources
Em busca de um primitivo de análise: o problema da representação do tap em grupos e em coda
Letras de Hoje, 2007 Este trabalho discute, com dados do Português Brasileiro (PB), a natureza dos primitivos de análise a serem adotados nas representações das línguas.
Nishida, Gustavo
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Revista PrincipiaEste trabalho é dedicado à simulação numérica do escoamento de gás natural em reservatórios não convencionais na presença dos efeitos de adsorção e escorregamento.
Grazione de Souza +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Revista de la Facultad de Medicina, 1996 Morfógenos, compartimentos y el patrón / Gradientes que organizan el desarrollo temprano / Mutaciones que causan mutaciones / El internet se autocensura?
Facultad de Medicina Revista
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