Results 111 to 120 of about 1,379,799 (331)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Gradientes térmicos en Andalucía
, 1993 Este trabajo es una aproximación al estudio de los gradientes térmicos en Andalucía. Para ello se ha divido el territorio en áreas topográficamente homogéneas a las que se ha aplicado el métedo de regresión lineal para la obtención de los valores del ...
Domínguez-Rodríguez, Rafael +3 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
La predicción del bajo peso y del peso insuficiente al nacer mediante la antropometría materna
Hacia la Promoción de la Salud, 2009 Objetivo: evaluar la capacidad pronóstica de un algoritmo para predecir el bajo peso y el peso insuficiente al nacer a partir de la antropometría materna.
María Victoria Benjumea Rincón +2 more
doaj
Regulação da resposta imunológica pelas células T no rato: mecanismos de interacção celular.
Acta Médica Portuguesa, 1979 Subpopulações de células T com funções helper ou supressora foram isoladas do baço do rato por fraccionamento em gradientes descontínuos de albumina. O estudo in vitro e in vivo da interacção destas populações celulares sugere a existência de um duplo ...
Benedita Rocha +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Microinestabilidades producidas por gradientes de corriente en plasmas magnetizados [PDF]
, 1984 Se estudian inestabilidades producidas por gradientes de velocidad y temperatura electrónica en un sustrato de plasma inmerso en un campo magnético con cizalladura.
Farengo, Ricardo
core +1 more source
, 2018 For a locally Lipschitz continuous function $f:X\to\mathbb{R}$ the generalized gradient $\partial f(x)$ of Clarke is used to develop some (set-valued) gradient on a set $A\subset X$. Existence, uniqueness and some approximation are considered for optimal descent directions on set $A$.
Mankau, Jan, Schuricht, Friedemann
openaire +3 more sources