Results 131 to 140 of about 1,379,799 (331)

Parâmetros fisiológicos, características de pelame e gradientes térmicos em novilhas nelore no verão e inverno em ambiente tropical

open access: yesBioscience Journal, 2013
Investigou-se a influência da estação do ano sobre as características termorreguladoras e de pelame bem como os gradientes térmicos em novilhas da raça Nelore.
Álvaro Moriya Shiota   +5 more
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Análisis de gradientes en elementos singulares cuadráticos de Serendipity y de Lagrange [PDF]

open access: yes, 1987
En el presente artículo se considera el tratamiento por el Metodo de Elementos Finitos de las singularidades que aparecen en la mecánica de la fractura en el caso elástico.
Gavete, Luis   +2 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Diversidade e assimetria flutuante em borboletas ao longo de gradientes urbanos [PDF]

open access: yes, 2019
Este estudo objetivou avaliar o efeito de gradientes de urbanização em parâmetros de comunidades de borboletas. Borboletas são organismos-modelo que permitem verificar a qualidade do habitat devido ao seu papel bioindicador.
Thaís Neres Guimarães Pignataro
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Cartografía de variables climáticas basada en gradientes, sistemas de expertos y SIG

open access: yesRevista Cubana de Meteorología, 2019
Se presenta un método para la generación de mapas continuos de variables climáticas a partir de gradientes, valores de referencia y criterio de expertos en zonas de relieve complejo.
Ricardo Delgado-Téllez   +1 more
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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