Results 141 to 150 of about 632,931 (308)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
mRNA diffusion explains protein gradients in Drosophila early development [PDF]
, 2009 We propose a new model describing the production and the establishment of the stable gradient of the Bicoid protein along the antero-posterior axis of the embryo of _Drosophila_.
Rui Dilao, Daniele Murro
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Galactic abundance gradients and implications for nucleosynthesis
, 2001 We present model calculations of the radial abundance gradients along the Galactic disk for elements He, C, N, O, Die, Mg, Al, Si, S, Ar and Fe on the basis of the metallicity dependent yields for massive stars with and without mass loss.
Hou, JL, Prantzos, N
core
Effect of salinity gradients on species composition of Odonata naiads [PDF]
, 2018 In present study the relationship between salinity gradients of various water bodies and inhabiting Odonata naiads was studied. Naiads, being a popular group of water pollution indicators, were studied.
Ahmed Zia +2 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
International Journal of Machine Learning and CyberneticsAbstract This paper presents a computationally efficient variant of Gradient Boosting (GB) for multi-class classification and multi-output regression tasks. Standard GB uses a 1-vs-all strategy for classification tasks with more than two classes. This strategy entails that one tree per class and iteration has to be trained.
Seyedsaman Emami +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
From gradients to cognition: linking cortical manifolds to brain flexibility and disorder
Frontiers in CognitionTraditional neuroscience describes the cerebral cortex as a mosaic of discrete, functionally specialized regions. However, a complementary view has emerged, demonstrating that the brain is also organized along continuous gradients that capture large ...
Joseph Y. Nashed +9 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source