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Heterotrimeric G Protein–RasGAP Coupling Drives Adaptation During Chemotaxis [PDF]

Cells
Chemotaxis enables eukaryotic cells to detect and migrate along extracellular chemoattractant gradients spanning several orders of magnitude. This remarkable dynamic range relies on adaptation, a process that allows cells to reset their signaling ...
Xuehua Xu, Riley D. Kim, Haneul Hyun, Ranti Dev Shukla, Tian Jin   +4 more
doaj   +2 more sources

Chemotaxis in cancer [PDF]

Nature Reviews Cancer, 2011
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how ...
Evanthia T Roussos, John Condeelis, Antonia Patsialou   +2 more
exaly   +3 more sources

Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors [PDF]

Journal of Neuroinflammation, 2022
Background Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis).
Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt, Anna Oevermann   +9 more
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Pseudomonas aeruginosa Performs Chemotaxis to the Neurotransmitters Serotonin, Dopamine, Epinephrine and Norepinephrine

Microbial Biotechnology
Bacteria use chemotaxis to move to favourable ecological niches. For many pathogenic bacteria, chemotaxis is required for full virulence, particularly for the initiation of host colonisation. There do not appear to be limits to the type of compounds that
Elizabet Monteagudo‐Cascales, Andrea Lozano‐Montoya, Tino Krell   +2 more
doaj   +2 more sources

C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis

Frontiers in Immunology, 2022
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown.
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin   +8 more
doaj   +1 more source

Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

Frontiers in Cell and Developmental Biology, 2021
Chemotaxis, which is G protein-coupled receptor (GPCR)-mediated directional cell migration, plays pivotal roles in diverse human diseases, including recruitment of leukocytes to inflammation sites and metastasis of cancer.
Xuehua Xu, Smit Bhimani, Henderikus Pots, Xi Wen, Taeck J. Jeon, Arjan Kortholt, Tian Jin   +6 more
doaj   +1 more source

Evolution of Reproductive Division of Labor – Lessons Learned From the Social Amoeba Dictyostelium discoideum During Its Multicellular Development

Frontiers in Cell and Developmental Biology, 2021
The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy, Shashi P. Singh   +1 more
doaj   +1 more source

Multiple CheY Proteins Control Surface-Associated Lifestyles of Azospirillum brasilense

Frontiers in Microbiology, 2021
Bacterial chemotaxis is the directed movement of motile bacteria in gradients of chemoeffectors. This behavior is mediated by dedicated signal transduction pathways that couple environment sensing with changes in the direction of rotation of flagellar ...
Elena E. Ganusova, Lam T. Vo, Tanmoy Mukherjee, Gladys Alexandre   +3 more
doaj   +1 more source

Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum

Biology, 2023
Differentiation-inducing factors 1 and 2 (DIF-1 and DIF-2) are small lipophilic signal molecules that induce stalk cell differentiation but differentially modulate chemotaxis toward cAMP in the cellular slime mold Dictyostelium discoideum; DIF-1 ...
Hidekazu Kuwayama, Haruhisa Kikuchi, Yuzuru Kubohara   +2 more
doaj   +1 more source

Cells collectively migrate during ammonium chemotaxis in Chlamydomonas reinhardtii

Scientific Reports, 2023
The mechanisms governing chemotaxis in Chlamydomonas reinhardtii are largely unknown compared to those regulating phototaxis despite equal importance on the migratory response in the ciliated microalga.
Gabela Nelson, Alexis Strain, Atsuko Isu, Alireza Rahnama, Ken-ichi Wakabayashi, Adam T. Melvin, Naohiro Kato   +6 more
doaj   +1 more source