Results 21 to 30 of about 328,071 (298)

Simplified Cell Magnetic Isolation Assisted SC² Chip to Realize “Sample in and Chemotaxis Out”: Validated by Healthy and T2DM Patients’ Neutrophils

Micromachines, 2022
Neutrophil migration in tissues critically regulates the human immune response and can either play a protective role in host defense or cause health problems. Microfluidic chips are increasingly applied to study neutrophil migration, attributing to their
Xiao Yang, Chaoru Gao, Yong Liu, Ling Zhu, Ke Yang   +4 more
doaj   +1 more source

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

Journal of Immunology Research, 2015
Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation.
Xuehua Xu, Tian Jin
doaj   +1 more source

Distinct Chemotaxis Protein Paralogs Assemble into Chemoreceptor Signaling Arrays To Coordinate Signaling Output

mBio, 2019
Most chemotactic motile bacteria possess multiple chemotaxis signaling systems, the functions of which are not well characterized. Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling ...
Lindsey O’Neal, Jessica M. Gullett, Anastasia Aksenova, Adam Hubler, Ariane Briegel, Davi Ortega, Andreas Kjær, Grant Jensen, Gladys Alexandre   +8 more
doaj   +1 more source

Quantitative Analysis of Cell Motility and Chemotaxis in Dictyostelium discoideum by Using an Image Processing System and a Novel Chemotaxis Chamber Providing Stationary Chemical Gradients [PDF]

, 1989
An image processing system was programmed to automatically track and digitize the movement of amebae under phase-contrast microscopy. The amebae moved in a novel chemotaxis chamber designed to provide stable linear attractant gradients in a thin agarose ...
G Gerisch, Fisher, P. R., Merkl, Rainer, Gerisch, G., P R Fisher, R Merkl   +5 more
core   +1 more source

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

Scientific Reports, 2021
Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad, Suaib Luqman, Chun-Hsiang Tan, Victoria Swann, Peter A. McNaughton   +4 more
doaj   +1 more source

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

Beilstein Journal of Organic Chemistry, 2018
Background: Cardiomyopathy induced by the chemotherapeutic agents doxorubicin and daunorubicin is a major limiting factor for their application in cancer therapy.
Livia Polgár, Eszter Lajkó, Pál Soós, Orsolya Láng, Marilena Manea, Béla Merkely, Gábor Mező, László Kőhidai   +7 more
doaj   +1 more source

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

Journal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic ...
Suman Kundu, Talat Roome, Ashish Bhattacharjee, Kevin A. Carnevale, Valentin P. Yakubenko, Renliang Zhang, Sung Hee Hwang, Bruce D. Hammock, Martha K. Cathcart   +8 more
doaj   +1 more source

Software: An automated approach to quantify chemotaxis index in C. elegans

, 2022
A command-line interface to measure chemotaxis index (CI) from chemotaxis assay imagesRelated ...
Timothy A Crombie
core   +1 more source

Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

eLife, 2017
Aspects of innate immunity derive from characteristics inherent to phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.
Netra Pal Meena, Alan R Kimmel
doaj   +1 more source

A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis

mBio, 2023
Pathogenic spirochetes can alter their morphologies and behaviors to infect and survive within their hosts. Previous reports demonstrate that the formation of the so-called “round bodies” and biofilms, and chemotaxis are involved in spirochete ...
A. R. Muok, K. Kurniyati, C. K. Cassidy, F. A. Olsthoorn, D. R. Ortega, A. Sidi Mabrouk, C. Li, A. Briegel   +7 more
doaj   +1 more source