Results 41 to 50 of about 328,071 (298)
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Identification of Positive Chemotaxis in the Protozoan Pathogen Trypanosoma brucei
mSphere, 2020 To complete its infectious cycle, the protozoan parasite Trypanosoma brucei must navigate through diverse tissue environments in both its tsetse fly and mammalian hosts. This is hypothesized to be driven by yet unidentified chemotactic cues.
Stephanie F. DeMarco +3 more
doaj +3 more sources
Counterclockwise rotation of the flagellum promotes biofilm initiation in Helicobacter pylori
mBioMotility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm formation ...
Xiaolin Liu +4 more
doaj +1 more source
Singly Flagellated
mBio, 2016 Pseudomonas aeruginosa is an opportunistic human pathogen that has long been known to chemotax. More recently, it has been established that chemotaxis is an important factor in the ability of P. aeruginosa to make biofilms. Genes that allow P. aeruginosa
Qiuxian Cai +4 more
doaj +1 more source
Bayes-Optimal Chemotaxis [PDF]
Neural Computation, 2011 Chemotaxis plays a crucial role in many biological processes, including nervous system development. However, fundamental physical constraints limit the ability of a small sensing device such as a cell or growth cone to detect an external chemical gradient.
Duncan Mortimer +3 more
openaire +5 more sources
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Enhancer of zeste homolog 2 enhances the migration and chemotaxis of dental mesenchymal stem cells
Journal of International Medical Research, 2020 Objective To investigate the function of enhancer of zeste homolog 2 (EZH2) in the migration and chemotaxis of human dental tissue-derived mesenchymal stem cells. Methods The expression of EZH2, C-X-C motif chemokine ligand 11 (CXCL11), CXCL16, and CXCR1
Huarui Ma +6 more
doaj +1 more source
chemotaxis of rhizobium phaseoli towards flavones and other related compounds [PDF]
, 1987 The formation of nitrogen-fixing nodules on leguminous plants is the result of a highly specific interaction between the host plant and the soil bacterium Rhizobium.
Munoz Aguilar, Jose Manuel
core
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]
, 2014 The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
Gabriela Kalna (192504) +92 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source