Results 11 to 20 of about 276,157 (197)

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

open access: yesJournal of Immunology Research, 2015
Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation.
Xuehua Xu, Tian Jin
doaj   +1 more source

Distinct Chemotaxis Protein Paralogs Assemble into Chemoreceptor Signaling Arrays To Coordinate Signaling Output

open access: yesmBio, 2019
Most chemotactic motile bacteria possess multiple chemotaxis signaling systems, the functions of which are not well characterized. Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling ...
Lindsey O’Neal   +8 more
doaj   +1 more source

Sperm chemotaxis in marine invertebrates and mammals

open access: yesReproductive and Developmental Medicine, 2017
Sperm respond to multiple chemical factors derived from the eggs and reorient their migratory direction – a process called chemotaxis. The chemotaxis of sperm in marine invertebrates has been established well.
Hang Kang   +3 more
doaj   +1 more source

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

open access: yesScientific Reports, 2021
Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad   +4 more
doaj   +1 more source

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

open access: yesBeilstein Journal of Organic Chemistry, 2018
Background: Cardiomyopathy induced by the chemotherapeutic agents doxorubicin and daunorubicin is a major limiting factor for their application in cancer therapy.
Livia Polgár   +7 more
doaj   +1 more source

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

open access: yesJournal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic ...
Suman Kundu   +8 more
doaj   +1 more source

Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

open access: yeseLife, 2017
Aspects of innate immunity derive from characteristics inherent to phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.
Netra Pal Meena, Alan R Kimmel
doaj   +1 more source

A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis

open access: yesmBio, 2023
Pathogenic spirochetes can alter their morphologies and behaviors to infect and survive within their hosts. Previous reports demonstrate that the formation of the so-called “round bodies” and biofilms, and chemotaxis are involved in spirochete ...
A. R. Muok   +7 more
doaj   +1 more source

The Novel Protein Cj0371 Inhibits Chemotaxis of Campylobacter jejuni

open access: yesFrontiers in Microbiology, 2018
cj0371 is a novel gene that is associated with Campylobacter jejuni virulence, and an isogenic mutant of cj0371 showed hyper chemotaxis and motility. Chemotactic motility is an important virulence factor and is involved in C.
Xueqing Du   +5 more
doaj   +1 more source

A minimal model of metabolism-based chemotaxis. [PDF]

open access: yesPLoS Computational Biology, 2010
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption.
Matthew D Egbert   +2 more
doaj   +1 more source

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