Results 11 to 20 of about 280,831 (264)

Simplified Cell Magnetic Isolation Assisted SC2 Chip to Realize “Sample in and Chemotaxis Out”: Validated by Healthy and T2DM Patients’ Neutrophils

open access: yesMicromachines, 2022
Neutrophil migration in tissues critically regulates the human immune response and can either play a protective role in host defense or cause health problems. Microfluidic chips are increasingly applied to study neutrophil migration, attributing to their
Xiao Yang   +4 more
doaj   +1 more source

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

open access: yesJournal of Immunology Research, 2015
Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation.
Xuehua Xu, Tian Jin
doaj   +1 more source

Distinct Chemotaxis Protein Paralogs Assemble into Chemoreceptor Signaling Arrays To Coordinate Signaling Output

open access: yesmBio, 2019
Most chemotactic motile bacteria possess multiple chemotaxis signaling systems, the functions of which are not well characterized. Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling ...
Lindsey O’Neal   +8 more
doaj   +1 more source

Chemotaxis in Childhood [PDF]

open access: yesPediatric Research, 1983
Developmental aspects of monocyte and neutrophil chemotaxis were evaluated by the agarose and the Boyden chamber methods. Simultaneous measurements of both the distances and the cell counts were carried out by the agarose method. Before 6 years of age monocyte chemotaxis values, determined by the Boyden chamber method, were significantly lower than ...
openaire   +3 more sources

Eukaryotic chemotaxis [PDF]

open access: yesWIREs Systems Biology and Medicine, 2009
AbstractDuring eukaryotic chemotaxis, external chemical gradients guide the crawling motion of cells. This process plays an important role in a large variety of biological systems and has wide ranging medical implications. New experimental techniques including confocal microscopy and microfluidics have advanced our understanding of chemotaxis while ...
Wouter-Jan, Rappel, William F, Loomis
openaire   +2 more sources

Sperm chemotaxis in marine invertebrates and mammals

open access: yesReproductive and Developmental Medicine, 2017
Sperm respond to multiple chemical factors derived from the eggs and reorient their migratory direction – a process called chemotaxis. The chemotaxis of sperm in marine invertebrates has been established well.
Hang Kang   +3 more
doaj   +1 more source

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

open access: yesBeilstein Journal of Organic Chemistry, 2018
Background: Cardiomyopathy induced by the chemotherapeutic agents doxorubicin and daunorubicin is a major limiting factor for their application in cancer therapy.
Livia Polgár   +7 more
doaj   +1 more source

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

open access: yesJournal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic ...
Suman Kundu   +8 more
doaj   +1 more source

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

open access: yesScientific Reports, 2021
Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad   +4 more
doaj   +1 more source

Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

open access: yeseLife, 2017
Aspects of innate immunity derive from characteristics inherent to phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.
Netra Pal Meena, Alan R Kimmel
doaj   +1 more source

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