Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Benzodiazepine receptor agonist deprescribing principles for long-term use and dependence: modified Delphi recommendations from a multi-disciplinary expert panel. [PDF]
Ther Adv PsychopharmacolBrandt J +8 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Gradual step-up weaning improves liberation in chronically ventilated tracheostomized patients. [PDF]
Crit Care SciColombo C, Teixeira C, Vieira SRR.
europepmc +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
, 2014 This work focuses on the modeling of multistage stochastic problems with endogenous (decision dependent) uncertainties. We assume that the probability distributions of the uncertain parameters are discrete, so that a scenario tree representation can be ...
Bora Tarhan B +4 more
core
Cognitive-Motor Dual-Task Training (CMDT) Approaches for Performance, Recovery, Injury Prevention, Rehabilitation, and Return to Sport in Soccer: A Narrative Review with Practical Recommendations for Soccer Clubs. [PDF]
J Funct Morphol KinesiolShalom A +2 more
europepmc +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Effect of the initial combination approach vs initial monotherapy approach on 1-year trajectories of adherence in drug-naive patients with type 2 diabetes. [PDF]
J Manag Care Spec PharmFatima B +3 more
europepmc +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley +1 more source