Results 61 to 70 of about 2,343,027 (301)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Bezmiâlem ScienceThis study was conducted to examine the postgraduate theses on palliative care in nursing in Türkiye and to reveal the nursing practices used. The population of the retrospective descriptive study consisted of theses in the field of nursing registered in
Elif Tuğba UYGUN, Aylin ÖZAKGÜL
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
, 2015 Annual publication of degrees offered and their requirements for all graduate students enrolled at the University of Central ...
Jackson College of Graduate Studies
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Üniversite Mezunlarının Kaygı Düzeylerinin İncelenmesi
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2014 Üniversite eğitimi, çeşitli sektörlerde işgörecek elemanlarıtemel eğitimden geçirerek işdünyasına hazırlamaktır. Üniversite dönemi olarak adlandırılan bu zaman parçasıise gençlerin yaşamlarının karar verme ile ilgili en önemli paya sahip olan bölümüdür ...
Necla Tektaş
doaj