Results 161 to 170 of about 14,049,689 (261)

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

open access: yesAdvanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma   +14 more
wiley   +1 more source

An Exploration of Competency Assessment in Graduate Medical Education. [PDF]

open access: yesJ Grad Med Educ
Marcotte KM   +8 more
europepmc   +1 more source

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

open access: yesAdvanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang   +4 more
wiley   +1 more source

Improving and Sustaining Equity Content and Quality in Graduate Medical Education. [PDF]

open access: yesJ Grad Med Educ
Jaen GS   +7 more
europepmc   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

open access: yesAdvanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal   +25 more
wiley   +1 more source

Organizational Psychology Theories in Graduate Medical Education: A Narrative Review. [PDF]

open access: yesHCA Healthc J Med
Saad MS   +4 more
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

open access: yesAdvanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu   +12 more
wiley   +1 more source

Neutrophil/Lymphocyte Ratio as a Predictive Biomarker of NIV Failure in AECOPD: The Unveiled Facts [Letter]

open access: yesInternational Journal of COPD
Dipasri Bhattacharya,1 Antonio M Esquinas,2 Mohanchandra Mandal3 1Department of Anaesthesiology, Pain Medicine and Critical Care, R.G.Kar Medical College & Hospital, Kolkata, West Bengal, India; 2Critical Care Specialist and Staff Physician ...
Bhattacharya D, Esquinas AM, Mandal M
doaj  

Starting strong: Evaluation of a graduate medical education wide virtual health equity orientation workshop. [PDF]

open access: yesJ Natl Med Assoc
Nwora C   +8 more
europepmc   +1 more source

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