Results 201 to 210 of about 298,429 (261)

Computation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases

Advanced Science, EarlyView.
This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie   +10 more
wiley   +1 more source

Leading Major Change in Graduate Medical Education: Initiate, Implement, and Sustain. [PDF]

J Grad Med Educ
Peters H, Jardine D, Joseph M.
europepmc   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source

Tracking Trainee Movement: A Scalable Framework for Analyzing Geographic Retention in Graduate Medical Education. [PDF]

J Grad Med Educ
Garten B, Bhatt AN, Patel R, Nulu C, Vuppala R, Moumne M, Kotireddy V, Gohel I, Amjad M, Kirolos A, Yakoub D, Estes A.   +11 more
europepmc   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Tracks and Pathways in Graduate Medical Education: Toward a Shared Mental Model. [PDF]

J Grad Med Educ
Crecelius T, Biddick N, Ricotta DN, Nelson RE.   +3 more
europepmc   +1 more source

Sex, Race, and Ethnicity Differences Among Residents With Exceptionally High Graduate Medical Education Ratings.

JAMA Netw Open
Kim JG, Hauer KE, Boscardin CK, Su JI, Holmboe ES, Konopasek L, Chen IL, Gonzalez CM, Ogedegbe GG, Burk-Rafel J, Nguyen M, Andrews JS, Henderson DD, Richardson J, McDade W, Boatright D.   +15 more
europepmc   +1 more source

Quantum Thinking in Graduate Medical Education: Transforming Minds, Methods, and Possibilities. [PDF]

J Grad Med Educ
Surapaneni KM.
europepmc   +1 more source

Change Management and Innovation in Graduate Medical Education. [PDF]

J Grad Med Educ
Caretta-Weyer HA, Coe CL, Co JPT, Fancher TL, Hammoud MM, DeWaters AL.   +5 more
europepmc   +1 more source

The Orphaned Resident and Graduate Medical Education Program Closures. [PDF]

J Grad Med Educ
Keneally RJ, Frazier HA.
europepmc   +1 more source