Results 141 to 150 of about 179,002 (365)

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research [PDF]

, 2016
The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules.
Abdel-Azim, H, Arora, M, Askar, M, Bitan, M, Dandoy, C, Drobyski, W, Fernandez-Viña, MA, Gandhi, M, Hale, G, Horowitz, MM, Lazaryan, A, Lee, SJ, Marsh, SG, Müller, CR, Nishihori, T, Olsson, R, Oudshoorn, M, Page, K, Pidala, J, Reshef, R, Savani, B, Schultz, K, Spellman, SR, Verneris, MR, Wang, HL, Wang, T, Weisdorf, DJ, Yong, A   +27 more
core   +4 more sources

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation

Advanced Science, EarlyView.
With emphasis on a diabetic state, this study highlights the role of mesenchymal stem cells (MSCs) in enhancing vascularization and modulating immune responses within a subcutaneous platform for cell transplantation for type 1 diabetes (T1D). Comprehensive profiling of MSC‐induced angiogenic and immune responses, provides insight into the role of MSCs ...
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids

Haematologica, 2011
Background Advances in acute graft-versus-host disease therapy are needed.Design and Methods We examined the efficacy of sirolimus as primary therapy for acute graft-versus-host disease in 32 patients.Results Acute graft-versus-host disease involved the ...
Joseph Pidala, Marcie Tomblyn, Taiga Nishihori, Teresa Field, Ernesto Ayala, Janelle Perkins, Hugo Fernandez, Fred Locke, Lia Perez, Jose Leonel Ochoa, Melissa Alsina, Claudio Anasetti   +11 more
doaj   +1 more source

Graft Versus Host Disease

Canadian Journal of General Internal Medicine, 1970
Graft Versus Host Disease (GVHD) is a rare complication of liver transplantation with a mortality rate exceeding 65%. A 53-year-old male presented with a diffuse maculopapular rash, diarrhea, lymphopenia, fever, and confusion 14 days after orthotopic liver transplantation for hepatitis B cirrhosis.
Janeve Desy, Marc Deschenes
openaire   +2 more sources

Potential Mechanisms of Photopheresis in Hematopoietic Stem Cell Transplantation [PDF]

, 2006
Immune tolerance describes specific unresponsiveness to antigens. In clinical situations such as graft-versus-host disease it may be useful to capitalize on these pre-existing tolerance mechanisms to treat patients.
Peritt, David
core   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

Advanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová, Francisco Javier Rodriguez‐Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Ana Artero‐Castro, Ruslan Nyshchuk, Anastasiia Kolesnikova, Brigitte Müller, Hana Studenovska, Jana Juhasova, Stefan Juhas, Ivona Valekova, Dunja Lukovic, Claudia Aleman, Taras Ardan, Saskia Drutovič, Jan Motlik, Zdenka Ellederova, Zbinek Straňák, Miroslav Veith, Lyubomyr Lytvynchuk, Ruchi Sharma, Kapil Bharti, Goran Petrovski, Pavla Jendelova, Knut Stieger, Slaven Erceg   +27 more
wiley   +1 more source

Pan-disease clustering analysis of the trend of period prevalence [PDF]

arXiv, 2018
For all diseases, prevalence has been carefully studied. In the "classic" paradigm, the prevalence of different diseases has usually been studied separately. Accumulating evidences have shown that diseases can be "correlated". The joint analysis of prevalence of multiple diseases can provide important insights beyond individual-disease analysis ...
arxiv  

The Effect of MyD88 Deficiency During Graft-Versus-Host Disease [PDF]

, 2011
Graft-versus-host disease is the onset of an un- wanted immune response in patients who have undergone bone marrow transplantation [1]. The effect of this unwanted immune response is lethal in many cases. The goal of this research is to reduce the effect
Choi, E. Y., Choi, Sean, Jeon, J. Y., Ju, J. M., Lee, H. Y.   +4 more
core   +1 more source

Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control

Advanced Science, EarlyView.
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui, Wonjoon Moon, Pu‐Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey A. Gelfand, Seok‐Hyun Yun   +12 more
wiley   +1 more source