Results 31 to 40 of about 117,056 (302)

Improved Overall Survival, Relapse-Free-Survival, and Less Graft-vs.-Host-Disease in Patients With High Immune Reconstitution of TCR Gamma Delta Cells 2 Months After Allogeneic Stem Cell Transplantation

open access: yesFrontiers in Immunology, 2019
T-cell receptor (TCR) γδ cells are perceived as innate-like effector cells with the possibility of mediating graft-vs. -tumor (GVT) without causing graft-vs.-host disease (GVHD) in the setting of hematopoietic allogeneic stem cell transplantation (HSCT).
L. Minculescu   +11 more
semanticscholar   +1 more source

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

open access: yesFrontiers in Immunology, 2019
Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD).
C. Grégoire   +13 more
semanticscholar   +1 more source

Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study

open access: yesFrontiers in Immunology, 2018
Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid ...
X. Qi   +7 more
semanticscholar   +1 more source

Treatments and supportive therapies for oral manifestations of chronic graft-versus-host disease

open access: yesActa Scientiarum. Health Sciences, 2016
The aim of this study was to conduct a systematic review of treatments and therapies for oral manifestations of chronic graft-versus-host disease, aiming at improving patients’ quality of life and mainly the reduction of mortality caused by graft-versus-
Rafaella Gabriel Maiolino   +5 more
doaj   +1 more source

Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease

open access: yesHaematologica, 2015
Effective pharmacological strategies employed in allogeneic hematopoietic cell transplantation should prevent serious chronic graft-versus-host disease and facilitate donor-recipient immune tolerance.
Joseph Pidala   +15 more
doaj   +1 more source

Post-Transplantation Cyclophosphamide vs Tacrolimus and Methotrexate Graft-versus-Host Disease Prophylaxis For HLA-Matched Donor Transplantation.

open access: yesTransplantation and Cellular Therapy, 2022
BACKGROUND The use of post-transplantation cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis is increasing in patients undergoing HLA-matched sibling (MSD) or unrelated (MUD) donor hematopoietic cell transplantation (HCT), but data
R. Mehta   +17 more
semanticscholar   +1 more source

Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil

open access: yesHematology, Transfusion and Cell Therapy, 2018
Background: Hematopoietic stem cell transplantation is a curative treatment for many patients with hematological disorders. Donor–recipient genetic disparity, especially involving the human leukocyte antigen system is a critical factor for transplant ...
Alessandra Paz   +12 more
doaj   +1 more source

Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3

open access: yesFrontiers in Immunology, 2020
Graft-versus-host disease (GvHD) remains the second leading cause of death in allogeneic hematopoietic stem cell transplantation recipients, highlighting the need for improved preventative strategies.
Megan S. Molina   +14 more
doaj   +1 more source

Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease

open access: yesStem Cell Research, 2019
The immune-mediated tissue destruction of graft-vs-host disease (GvHD) remains a major barrier to greater use of hematopoietic stem cell transplantation (HSCT).
E. I. Ozay   +13 more
semanticscholar   +1 more source

Ruxolitinib treatment for steroid refractory acute and chronic graft vs host disease in children: Clinical and immunological results

open access: yesAmerican journal of hematology/oncology, 2018
Ruxolitinib is a promising treatment for steroid refractory graft‐vs‐host disease (GvHD). However, data concerning effects on T cells are probably involved in increased risk of opportunistic infections.
M. González Vicent   +4 more
semanticscholar   +1 more source

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