Results 31 to 40 of about 41,957 (164)

Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease

Frontiers in Immunology, 2019
Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders.
Govindarajan Thangavelu, Bruce R. Blazar
doaj   +1 more source

CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation

Frontiers in Immunology, 2019
Since their discovery CD4+FOXP3+ regulatory T cells (Tregs) represented a promising tool to induce tolerance in allogeneic hematopoietic cell transplantation.
Antonella Mancusi, Sara Piccinelli, Andrea Velardi, Antonio Pierini   +3 more
doaj   +1 more source

Comparison of the Efficacy of Topical Triamcinolone in Orabase and Curcumin in Orabase in Oral Graft-versus-Host Disease

Frontiers in Dentistry, 2017
Objectives: Graft-versus-host disease (GVHD) is among the most frequent complications of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD has several clinical manifestations in the oral cavity, including painful desquamative erythema ...
Arash Mansourian, Babak Bahar, Mahdieh Sadat Moosavi, Massoud Amanlou, Shahabodin Babaeifard   +4 more
doaj  

Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity and cancer

Frontiers in Immunology, 2013
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance.
Erin E Hillhouse, Jean-Sébastien eDelisle, Sylvie eLesage   +2 more
doaj   +1 more source

MiR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence

Frontiers in Immunology, 2016
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous haematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality.
Sadaf eAtarod, Mohammed Mahid Ahmed, Clare eLendrem, Kim Frances Pearce, Wei eCope, Jean eNorden, Xiao-Nong eWang, Matthew eCollin, Anne Mary Dickinson   +8 more
doaj   +1 more source

Using Gene Editing Approaches to Fine-Tune the Immune System

Frontiers in Immunology, 2020
Genome editing technologies not only provide unprecedented opportunities to study basic cellular system functionality but also improve the outcomes of several clinical applications.
Kristina Pavlovic, Kristina Pavlovic, María Tristán-Manzano, Noelia Maldonado-Pérez, Marina Cortijo-Gutierrez, Sabina Sánchez-Hernández, Pedro Justicia-Lirio, Pedro Justicia-Lirio, M. Dolores Carmona, Concha Herrera, Concha Herrera, Francisco Martin, Karim Benabdellah   +12 more
doaj   +1 more source

A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation

Haematologica, 2014
The study is a randomized phase II trial investigating graft-versus-host disease prophylaxis after non-myeloablative (90 mg/m2 fludarabine and 2 Gy total body irradiation) human leukocyte antigen matched unrelated donor transplantation.
Brian Kornblit, David G. Maloney, Barry E. Storer, Michael B. Maris, Lars Vindeløv, Parameswaran Hari, Amelia A. Langston, Michael A. Pulsipher, Wolfgang A. Bethge, Thomas R. Chauncey, Thoralf Lange, Finn B. Petersen, Kai Hübel, Ann E. Woolfrey, Mary E.D. Flowers, Rainer Storb, Brenda M. Sandmaier   +16 more
doaj   +1 more source

The Epitope-Specific Anti-human CD4 Antibody MAX.16H5 and Its Role in Immune Tolerance

Frontiers in Immunology, 2019
T cell modulation in the clinical background of autoimmune diseases or allogeneic cell and organ transplantations with concurrent preservation of their natural immunological functions (e.g., pathogen defense) is the major obstacle in immunology.
Lilly Stahl, Anna Duenkel, Nadja Hilger, Uta Sandy Tretbar, Stephan Fricke   +4 more
doaj   +1 more source

[Control of graft-vs-host disease].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1990
Considering the merit and demerit of GVHD in leukemia patients following allogeneic BMT, our strategies for GVHD are as follows; (1) a mild prevention, (2) a treatment to control the severity, if occurred, and (3) an induction of GVHD in recipients who did not develop GVHD. We reported the results of recent trials in prevention, treatment and induction
openaire   +2 more sources

Expanding Role of Gastroenterologists in Acute Gastrointestinal Graft-versus-Host Disease: From Diagnosis and Management to Microbiome-Based Strategies

The Korean Journal of Gastroenterology
Acute graft-versus-host disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation. Steroid-refractory cases have poor outcomes, so an accurate diagnosis, particularly differentiation from cytomegalovirus colitis,
Seung Bum Lee
doaj   +1 more source