Results 41 to 50 of about 41,957 (164)
Toll-Like Receptor Stimulation by MicroRNAs in Acute Graft-vs.-Host Disease
Frontiers in Immunology, 2018 Acute graft-vs.-host disease (aGVHD) is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), accounting for substantial morbidity and mortality associated with this treatment modality.
Nina C. Zitzer +3 more
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OncoImmunology, 2017 The demethylating agent 5-azacytidine (AZA) has proven its efficacy in the treatment of myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg).
Grégory Ehx +11 more
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The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease
Frontiers in Immunology, 2019 Allogeneic hematopoietic cell transplantation (allo-HCT) is performed with curative intent for high- risk blood cancers and bone marrow failure syndromes; yet the development of acute and chronic graft-vs.-host disease (GVHD) remain preeminent causes of ...
David Bastian +4 more
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Cytokine Detection and Modulation in Acute Graft vs. Host Disease in Mice
Mediators of Inflammation, 1994 A murine model for acute lethal graft vs. host disease (GVHD) was used to study the role that a number of cytokines play in the development of lethal GVHD. In this study we focused on the role of IL-1, IL-2, IL-4, IL-6, IFN-γ and TNF-α.
A. C. Knulst +6 more
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Frontiers in Bioengineering and Biotechnology, 2018 The most effective treatment of steroid refractory acute graft vs. host disease (aGvHD) is not yet established and mesenchymal stem cells (MSC) appear to be a promising therapy for the condition. We report single center case series of three patients, who
Maja Česen Mazič +4 more
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Complement and CD4+ T cells drive context-specific corneal sensory neuropathy
eLife, 2019 Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear.
Derek J Royer +7 more
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Looking into nerve damage in the cornea
eLife, 2019 Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
Mihaela Gadjeva
doaj +1 more source
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Nature Communications, 2017 Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the ...
Satish Ranjan +24 more
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The influence of dental care associated with laser therapy on oral mucositis during allogeneic hematopoietic cell transplant: retrospective study [PDF]
Einstein (São Paulo), 2011 Objective: To verify decrease in frequency and severity of oralmucositis in patients submitted to dental care and laser therapyduring allogeneic hematopoietic cell transplant.
Fernanda de Paula Eduardo +6 more
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