Results 1 to 10 of about 556,351 (216)

Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Frontiers in Oncology, 2021
Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers.
Marion Grard, Marion Grard, Camille Chatelain, Camille Chatelain, Tiphaine Delaunay, Tiphaine Delaunay, Elvire Pons-Tostivint, Elvire Pons-Tostivint, Elvire Pons-Tostivint, Jaafar Bennouna, Jaafar Bennouna, Jaafar Bennouna, Jean-François Fonteneau, Jean-François Fonteneau   +13 more
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The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes

Frontiers in Immunology, 2023
Despite significant advances, the eradication of cancer remains a clinical challenge which justifies the urgent exploration of additional therapeutic strategies such as immunotherapies.
Chirine Rafia, Chirine Rafia, Clément Loizeau, Clément Loizeau, Ophélie Renoult, Ophélie Renoult, Christelle Harly, Christelle Harly, Claire Pecqueur, Claire Pecqueur, Noémie Joalland, Noémie Joalland, Emmanuel Scotet, Emmanuel Scotet   +13 more
doaj   +1 more source

Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells

Frontiers in Immunology, 2020
Despite recent advances, the eradication of cancers still represents a challenge which justifies the exploration of additional therapeutic strategies such as immunotherapies, including adoptive cell transfers.
Noémie Joalland, Noémie Joalland, Emmanuel Scotet, Emmanuel Scotet   +3 more
doaj   +1 more source

High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma

Molecular Therapy: Oncolytics, 2020
Malignant pleural mesothelioma (MPM) is a cancer of the pleura that lacks efficient treatment. Oncolytic immunotherapy using oncolytic vaccinia virus (VV) may represent an alternative therapeutic approach for the treatment of this malignancy.
Tiphaine Delaunay, Joelle Nader, Marion Grard, Isabelle Farine, Vera Hedwig, Johann Foloppe, Thibaut Blondy, Mathilde Violland, Daniel Pouliquen, Marc Grégoire, Nicolas Boisgerault, Philippe Erbs, Jean-François Fonteneau   +12 more
doaj   +1 more source

IL‐7 is expressed in malignant mesothelioma and has a prognostic value

Molecular Oncology, 2022
Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients.
Hoa‐Le Mai, Sophie Deshayes, Thi‐Van‐Ha Nguyen, Virginie Dehame, Anne‐Laure Chéné, Sophie Brouard, Christophe Blanquart   +6 more
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Scaling the Graft Length and Graft Density of Irradiation‐Grafted Copolymers [PDF]

Macromolecular Chemistry and Physics, 2018
AbstractIrradiation‐induced graft copolymerization is often the easiest route to combine the functionality of two polymers and, furthermore, the average composition of the copolymer is straightforward to control. However, control of the graft length and the graft density is more difficult and has been considered to be infeasible. To test the hypothesis
Gergely Nagy, Véronique Sproll, Urs Gasser, Thomas J. Schmidt, Lorenz Gubler, Sandor Balog   +5 more
openaire   +2 more sources

Regulatory B cells: an exciting target for future therapeutics in transplantation

Frontiers in Immunology, 2014
Transplantation is the preferred treatment for most end-stage solid organ diseases. Despite potent immunosuppressive agents, chronic rejection remains a real problem in transplantation. For many years, the predominant immunological focus of research into
Alexandre eNouël, Quentin eSimon, Christophe eJamin, Jacques-Olivier ePers, Sophie eHillion   +4 more
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IL-34 Actions on FOXP3+ Tregs and CD14+ Monocytes Control Human Graft Rejection

Frontiers in Immunology, 2020
Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without
Séverine Bézie, Séverine Bézie, Séverine Bézie, Antoine Freuchet, Antoine Freuchet, Antoine Freuchet, Céline Sérazin, Céline Sérazin, Céline Sérazin, Apolline Salama, Apolline Salama, Apolline Salama, Nadège Vimond, Nadège Vimond, Nadège Vimond, Ignacio Anegon, Ignacio Anegon, Ignacio Anegon, Carole Guillonneau, Carole Guillonneau, Carole Guillonneau   +20 more
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Cell-free chromatin immunoprecipitation to detect molecular pathways in heart transplantation

Life Science Alliance, 2023
Cell-free DNA chromatin immunoprecipitation detects molecular pathways and profiles the sources of tissue injury in heart transplant patients. Existing monitoring approaches in heart transplantation lack the sensitivity to provide deep molecular ...
Moon Kyoo Jang, Tovah E Markowitz, Temesgen E Andargie, Zainab Apalara, Skyler Kuhn, Sean Agbor-Enoh   +5 more
doaj   +1 more source

RANK-BASED ESTIMATION FOR COBB-DOUGLAS MODELLING IN THE PRESENCE OF OUTLIERS [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2018
Ordinary least square (OLS) has been widely used in estimating the Cobb-Douglas production function when analysing the empirical linkage between inputs and outputs.
Acquah De-Graft H.
doaj   +1 more source